Publications
Below are a selection of recent publications that showcase the Vapourtec technology.
Click here for list of peer reviewed publications
(or here to download whole list as a single PDF 
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Effect of phase transfer chemistry, segmented fluid flow, and sonication on the synthesis of cinnamic esters
Mauro Riccaboni, Elena La Porta, Andrea Martorana and Roberta Attanasio
Department of Medicinal Chemistry, NiKem Research Srl, Milan, Italy
http://dx.doi.org/10.1016/j.tet.2010.04.031
Continuous Flow Palladium(II)-Catalyzed Oxidative Heck Reactions with Arylboronic Acids
Luke R. Odell 1, Jonas Lindh 1, Tomas Gustafsson 2, Mats Larhed 1 *
1 Organic Pharmaceutical Chemistry, Department of MedChem, Uppsala University, Sweden
2 AstraZeneca R&D Mölndal, Sweden
http://dx.doi.org/10.1002/ejoc.201000063
Reaction of Grignard reagents with carbonyl compounds under continuous flow conditions
E. Riva1, S. Gagliardi2, M. Martinelli2, D. Passarella1, D. Vigo2 and A. Rencurosi2,
1 Dipartimento di Chimica Organica e Industriale, Università degli Studi di Milano, Via Venezian 21, 20133 Milano, Italy
2 NiKem Research S.r.l., , Milan, Italy
http://dx.doi.org/10.1016/j.tet.2010.02.078
[3+2] Dipolar cycloadditions of an unstabilised azomethine ylide under continuous flow conditions
Mark Grafton, Andrew C. Mansfield and M. Jonathan
Pfizer Global Research and Development, Sandwich, UK
http://dx.doi.org/10.1016/j.tetlet.2009.12.071
A highly efficient flow reactor process for the synthesis of N-Boc-3,4-dehydro-l-proline methyl ester
Lucia Tamborini, Paola Conti, Andrea Pinto and Carlo De Micheli
Dipartimento di Scienze Farmaceutiche ‘Pietro Pratesi’, Università degli Studi di Milano, Italy
http://dx.doi.org/10.1016/j.tetasy.2009.12.023
Efficient Continuous Flow Synthesis of Hydroxamic Acids and Suberoylanilide Hydroxamic Acid Preparation
E. Riva1, S. Gagliardi2, Caterina Mazzoni 2, M. Martinelli2, D. Passarella1, D. Vigo2 and A. Rencurosi2,
1 Dipartimento di Chimica Organica e Industriale, Università degli Studi di Milano, Via Venezian 21, 20133 Milano, Italy
2 NiKem Research S.r.l., Milan, Italy
http://dx.doi.org/10.1021/jo900144h
The application of flow microreactors to the preparation of a family of casein kinase I inhibitors
Francesco Venturoni, Nikzad Nikbin, Steven V. Ley and Ian R. Baxendale
Innovative Technology Centre, Department of Chemistry, University of Cambridge
http://dx.doi.org/10.1039/b925327k
Multi-Step Synthesis by Using Modular Flow Reactors: The Preparation of YneOnes and Their Use in Heterocycle Synthesis
Ian R. Baxendale1, Søren C. Schou2, Jörg Sedelmeier1, Steven V. Ley1
1ITC, Department of Chemistry, University of Cambridge
2LEO Pharma, Medicinal Chemistry Research, Denmark
http://dx.doi.org/10.1055/s-0029-1219431
A Flow Process Using Microreactors for the Preparation of a Quinolone Derivative as a Potent 5HT1B Antagonist
Zizheng Qian, Ian R. Baxendale, Steven V. Ley
Innovative Technology Centre, Department of Chemistry, University of Cambridge
http://dx.doi.org/10.1055/s-0029-1219358
A flow-based synthesis of Imatinib: the API of Gleevec
Mark D. Hopkin, Ian R. Baxendale and Steven V. Ley
Innovative Technology Centre, Department of Chemistry, University of Cambridge
http://dx.doi.org/10.1039/c001550d
ReactIR Flow Cell: A New Analytical Tool for Continuous Flow Chemical Processing
Catherine F. Carter1, Heiko Lange1, Steven V. Ley1, Ian R. Baxendale1, Brian Wittkamp2, Jon G. Goode3 and Nigel L. Gaunt3
1 Innovative Technology Centre, Department of Chemistry, University of Cambridge
2 Mettler-Toledo AutoChem, USA
3 Mettler-Toledo AutoChem, UK
http://dx.doi.org/10.1021/op900305v
A safe and reliable procedure for the iododeamination of aromatic and heteroaromatic amines in a continuous flow reactor
Laia Malet-Sanz , Julia Madrzak, Rhian S. Holvey and Toby Underwood
Research Chemistry, Pfizer Global Research and Development, Sandwich, UK
http://dx.doi.org/10.1016/j.tetlet.2009.10.007
Development of fluorination methods using continuous-flow microreactors
Marcus Baumann, Ian R. Baxendale, Laetitia J. Martin, Steven V. Ley
Innovative Technology Centre, Department of Chemistry, University of Cambridge
http://dx.doi.org/10.1016/j.tet.2009.05.083
Multistep Synthesis Using Modular Flow Reactors: Bestmann-Ohira Reagent for the Formation of Alkynes and Triazoles
Ian R. Baxendale1, Steven V. Ley1, Andrew C. Mansfield 2, Christopher D. Smith1
1ITC, Department of Chemistry, University of Cambridge,
2Pfizer Global R&D Research Centre, Sandwich, (UK)
http://dx.doi.org/10.1002/anie.200900970
A Bifurcated Pathway to Thiazoles and Imidazoles Using a Modular Flow Microreactor
Ian R. Baxendale, Steven V. Ley, Christopher D. Smith, Lucia Tamborini and Ana-Florina Voica
Innovative Technology Centre (ACS), Department of Chemistry, University of Cambridge
http://dx.doi.org/10.1021/cc800070a
The Use of Diethylaminosulfur Trifluoride (DAST) for Fluorination in a Continuous-Flow Microreactor
Baumann, Marcus, Baxendale, Ian R., Ley, Steven V.
Innovative Technology Centre, Department of Chemistry, University of Cambridge
http://dx.doi.org/10.1055/s-2008-1078026
A modular flow reactor for performing Curtius rearrangements as a continuous flow process
Marcus Baumann1, Ian R. Baxendale1, Steven V. Ley1, Nikzad Nikbin1, Christopher D. Smith1 and Jason P. Tierney2
1 Innovative Technology Centre, Department of Chemistry, University of Cambridge
2 Neurology Lead Discovery Chemistry, GlaxoSmithKline R and D, Harlow, UK
http://dx.doi.org/10.1039/b801631n
Azide monoliths as convenient flow reactors for efficient Curtius rearrangement reactions
Marcus Baumann, Ian R. Baxendale, Steven V. Ley, Nikzad Nikbin and Christopher D. Smith
Innovative Technology Centre, Department of Chemistry, University of Cambridge
http://dx.doi.org/10.1039/b801634h
A flow reactor process for the synthesis of peptides utilizing immobilized reagents, scavengers and catch and release protocols
Ian R. Baxendale, Steven V. Ley, Christopher D. Smith and Geoffrey K. Tranmer
Innovative Technology Centre, Department of Chemistry, University of Cambridge
http://dx.doi.org/10.1039/b612197g
Fully Automated Flow-Through Synthesis of Secondary Sulfonamides in a Binary Reactor System
Charlotte M. Griffiths-Jones, Mark D. Hopkin, Daniel Jönsson, Steven V. Ley, David J. Tapolczay, Emma Vickerstaffe, and Mark Ladlow
GlaxoSmithKline Cambridge Technology Centre, University Chemical Laboratory, Cambridge
http://dx.doi.org/10.1021/cc060152b
Continuous Flow Ligand-Free Heck Reactions Using Monolithic Pd [0] Nanoparticles
Nikzad Nikbin, Mark Ladlow, and Steven V. Ley
Department of Chemistry, University of Cambridge, UK
http://dx.doi.org/10.1021/op7000436
Tagged phosphine reagents to assist reaction work-up by phase-switched scavenging using a modular flow reactor
Christopher D. Smith, Ian R. Baxendale, Geoffrey K. Tranmer, Marcus Baumann, Stephen C. Smith, Russell A. Lewthwaite and Steven V. Ley
Department of Chemistry, University of Cambridge, UK
http://dx.doi.org/10.1039/b703033a
| Articles: |
| Follow the Pharma Flow (published in Speciality Chemicals magazine) |
