Publications: Micro Reactors: Flow Chemistry Equipment UK | www.vapourtec.co.uk
www.vapourtec.co.uk

Publications

 


To date, the Vapourtec R Series system has featured in 125 or more peer reviewed publications.

Follow the links below to see the sort of things that are possible, but note that most published papers will require a journal subscription.

 

Download all 125 papers listing as PDF file    

     
Click here to signup for bimonthly newsletter, so you can keep up to date with new research as it is published

 

 


Publications

 

 
Synthesis of All Four Stereoisomers of 3-(tert-Butoxycarbonyl)-3-azabicyclo[3.1.0]hexane-2-carboxylic Acid
Bettina Bakonyi, Markus Furegati*‡, Christian Kramer§, Luigi La Vecchia, and Flavio Ossola
Doetsch Grether AG, Falkensteinerstrasse 37, 4132 Muttenz, Switzerland
Preparations Laboratories, Global Discovery Chemistry, Novartis Institutes for Biomedical Research, Klybeckstrasse 141, 4057 Basel,Switzerland
§ Institute of General, Inorganic and Theoretical Chemistry and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innsbruck, Austria
http://dx.doi.org/10.1021/jo4013282
 
Seamless Integration of Dose-Response Screening and Flow Chemistry: Efficient Generation of Structure–Activity Relationship Data of ?-Secretase (BACE1) Inhibitors
Dr. Michael Werner1,*, Christoph Kuratli1,Dr. Rainer E. Martin1,*, Dr. Remo Hochstrasser1, David Wechsler1, Dr. Thilo Enderle1, Dr. Alexander I. Alanine1 and Prof. Dr. Horst Vogel2
1 Medicinal Chemistry, Small Molecule Research, Pharma Research & Early Development (pRED), F. Hoffmann-La Roche AG, Grenzacherstrasse 124, 4070 Basel (Switzerland)
2 Institute of Chemical Sciences and Engineering, Swiss Federal Institute of Technology of Lausanne (EPFL), Station 6, 1015 Lausanne (Switzerland)
http://dx.doi.org/10.1002/anie.201309301
 
Controlled synthesis of poly(3-hexylthiophene) in continuous flow
Helga Seyler, Jegadesan Subbiah, David J. Jones, Andrew B. Holmes and Wallace W. H. Wong*
School of Chemistry, Bio21 Institute, University of Melbourne, 30 Flemington Road, Parkville, Victoria 3010, Australia
*Corresponding author
http://dx.doi.org/10.3762/bjoc.9.170
 
Integration of enabling methods for the automated flow preparation of piperazine-2-carboxamide
Richard J. Ingham1, Claudio Battilocchio1, Joel M. Hawkins2 and Steven V. Ley1
1 Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW, Cambridge, UK
2 Pfizer Worldwide Research and Development, Eastern Point Road, Groton, CT 06340, USA
http://dx.doi.org/10.3762/bjoc.10.56
 
Sequential flow process for the controlled polymerisation and thermolysis of RAFT-synthesised polymers
CH Hornung, A Postma, S Saubern, J Chiefari
CSIRO Materials Science and Engineering, Victoria, Australia
http://dx.doi.org/10.1016/j.polymer.2014.01.023
 
Robust and reusable supported palladium catalysts for cross-coupling reactions in flow
William R. Reynolds,ab Pawel Plucinskibc and Christopher G. Frost*ab
* Corresponding authors
a Centre for Sustainable Chemical Technologies, University of Bath, Claverton Down, Bath, UK
b Department of Chemistry, University of Bath, Claverton Down, Bath, UK
c Department of Chemical Engineering, University of Bath, Claverton Down, Bath, UK
http://dx.doi.org/10.1039/C3CY00836C
 
Investigating the continuous synthesis of a nicotinonitrile precursor to nevirapine
Ashley R. Longstreet1, Suzanne M. Opalka1, Brian S. Campbell1, B. Frank Gupton2, Tyler McQuade1
1 Department of Chemistry and Biochemistry, Florida State University, United States
1 Department of Chemistry, Virginia Commonwealth University, United States
http://dx.doi.org/10.3762/bjoc.9.292
 
 
Porous, functional, poly(styrene-co-divinylbenzene) monoliths by RAFT polymerization
Kristine J. Barlow (née Tan), Xiaojuan Hao, Timothy C. Hughes, Oliver E. Hutt, Anastasios Polyzos, Kathleen A. Turner, Graeme Moad
Commonwealth Scientific and Industrial Research Organisation (CSIRO), Materials Science & Engineering, Australia
http://dx.doi.org/10.1039/C3PY01015E
 
New Insights into Cyclobutenone Rearrangements: A Total Synthesis of the Natural ROS-Generating Anti-Cancer Agent Cribrostatin 6
Mubina Mohamed1, Théo P. Gonçalves1, Prof. Richard J. Whitby1, Dr. Helen F. Sneddon2, Prof. David C. Harrowven1
1 Chemistry, University of Southampton, UK
2 GlaxoSmithKline Medicines Research Centre, UK
http://dx.doi.org/10.1002/chem.201102263
 
Hypervalent iodine/TEMPO-mediated oxidation in flow systems: a fast and efficient protocol for alcohol oxidation
Nida Ambreen, Ravi Kumar and Thomas Wirth
Innovative Technology Centre, Cardiff University, School of Chemistry, Park Place, Cardiff, UK
http://dx.doi.org/10.3762/bjoc.9.162
 
The application of a monolithic triphenylphosphine reagent for conducting Ramirez gem-dibromoolefination reactions in flow
Kimberley A. Roper1, Malcolm B. Berry2 and Steven V. Ley1,
1 Innovative Technology Centre, Department of Chemistry, University of Cambridge, Cambridge, U.K.
2 GlaxoSmithKline, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, U.K.
http://dx.doi.org/10.3762/bjoc.9.207
 
Flow-Based, Cerium Oxide Enhanced, Low-Level Palladium Sonogashira and Heck Coupling Reactions by Perovskite Catalysts
Claudio Battilocchio1, Benjamin N. Bhawal1, Rajeev Chorghade1, Benjamin J. Deadman1, Joel M. Hawkins2, Steven V. Ley1,
1 Innovative Technology Centre, Department of Chemistry, University of Cambridge, UK
2 Pfizer Worldwide Research & Development, Groton, USA
http://dx.doi.org/10.1002/ijch.201300049
 
 
The Fit For Purpose Development of S1P1 Receptor Agonist GSK2263167 Using a Robinson Annulation and Saegusa Oxidation to Access an Advanced Phenol Intermediate
Robert M. Harris, Benjamin I. Andrews, Stacy Clark,
Jason W. B. Cooke, John C. S. Gray, and Stephanie Q. Q. Ng
Chemical Development, GlaxoSmithKline Research and Development Ltd., UK
http://dx.doi.org/10.1021/op400162p
 
Raman spectroscopy as a tool for monitoring mesoscale continuous-flow organic synthesis: Equipment interface and assessment in four medicinally-relevant reactions
Trevor A. Hamlin and Nicholas E. Leadbeater
Department of Chemistry, University of Connecticut, USA
http://dx.doi.org/10.3762/bjoc.9.215
 
Biotransformation with whole microbial systems in a continuous flow reactor: resolution of (RS)-flurbiprofen using Aspergillus oryzae by direct esterification with ethanol in organic solvent
Lucia Tamborinia, Diego Romanob, Andrea Pintoa,Martina Contentea,Maria C. Iannuzzia, Paola Contia,Francesco Molinarib
a Dipartimento di Scienze Farmaceutiche, Universitá degli Studi di Milano, Italy
b Dipartimento di Scienze per gli Alimenti, la Nutrizione e l'Ambiente (DEFENS), Universitá degli Studi di Milano, Italy
http://dx.doi.org/10.1016/j.tetlet.2013.08.119
 
Continuous Flow Synthesis of Coumarin
Anbang Chen1, Xin Li1, Yangzhi Zhou1, Lingling Huang2, Zheng Fang2, Haifeng Gan1 and Kai Guo1,
1 College of Biotechnology and Pharmaceutical Engineering, Nanjing University of Technology
2 School of Pharmceutical Sciences, Nanjing University of Technology
http://dx.doi.org/10.4028/www.scientific.net/AMR.781-784.936
 
Flow-Based, Cerium Oxide Enhanced, Low-Level Palladium Sonogashira and Heck Coupling Reactions by Perovskite Catalysts
Claudio Battilocchio1, Benjamin N. Bhawal1, Rajeev Chorghade1, Benjamin J. Deadman1, Joel M. Hawkins2, Steven V. Ley1,
1 Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2?1EW (UK), Fax: (+)44?(0)1223?336442
2 Pfizer Worldwide Research & Development, Eastern Point Road, Groton, CT 06340 (USA)
http://dx.doi.org/10.1002/ijch.201300049
 
 
Continuous Flow-Processing of Organometallic Reagents Using an Advanced Peristaltic Pumping System and the Telescoped Flow Synthesis of (E/Z)-Tamoxifen
Philip R D Murray, Duncan L Browne
Julio C Pastre, Chris Butters
Duncan Guthrie, Steven V Ley
Department of Chemistry, University of Cambridge, UK
Instituto de Química, University of Campinas, Brazil
Vapourtec Ltd, UK
http://dx.doi.org/10.1021/op4001548 

Click here for more details about the publication

 
First Example of Alkyl-Aryl Negishi Cross-Coupling in Flow: Mild, Efficient and Clean Introduction of Functionalized Alkyl Groups
Brecht Egle. Juan M. Muñoz1. Nerea Alonso, Wim M. Borggraeve
Antonio Hoz, Angel Díaz-Ortiz, Jesús Alcázar.
Janssen Research and Development Department of Medicinal Chemistry, Janssen-Cilag, Spain.
Department of Chemistry, Molecular Design and Synthesis University of Leuven, Belgium.
Universidad de Castilla-La Mancha Facultad de Ciencias y Tecnologías Químicas, Spain.
http://dx.doi.org/10.1556/JFC-D-13-00009  
 
Microwave heating and conventionally-heated continuous-flow processing as tools for performing cleaner palladium-catalyzed decarboxylative couplings using oxygen as the oxidant – a proof of principle study
DiAndra Rudzinski.
Nicholas Leadbeater.
Department of Chemistry, University of Connecticut, USA.
http://dx.doi.org/10.1515/gps-2013-0043  
 
Integrated Synthesis and Testing of Substituted Xanthine Based DPP4 Inhibitors: Application to Drug Discovery
Werngard Czechtizky, Jurgen Dedio, Bimbisar Desai, Karen Dixon, Elizabeth Farrant, Qixing Feng Trevor Morgen, David M Parry, Manoj K. Ramjee,
Christopher N. Selway, Thorsten Schmidt, Gary J. Tarver, Adrian G. Wright
Sanofi-Aventis, Frankfurt, Germany.
Cyclofluidic Ltd., U.K.
http://dx.doi.org/10.1021/ml400171b
 
The rapid generation of isothiocyanates in flow
Marcus Baumann
Ian R. Baxendale
Department of Chemistry, University of Durham, U.K.
http://dx.doi.org/10.3762/bjoc.9.184
 
 

Rapid Discovery of a Novel Series of Abl Kinase Inhibitors by Application of an Integrated Microfluidic Synthesis and Screening Platform

Bimbisar Desai.  Karen Dixon.  Elizabeth Farrant, Qixing Feng
Karl R. Gibson, Willem P. van Hoorn. James Mills, Trevor Morgan
David M. Parry, Manoj K. Ramjee, Christopher Nicholas Selway
Gary J. Tarver, Gavin Whitlock, Adrian G. Wright
Cyclofluidic Ltd.
 
 
 
A Multi-Step Continuous Flow Process for the N-Demethylation of Alkaloids
Yuji Nakano 1
G. Paul Savage 1 
Simon Saubern 1
Peter J. Scammells 2
Anastasios Polyzos 1 
1 CSIRO Materials Science and Engineering, Victoria, Australia. 
2 Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Victoria, Australia. 
 
 
 
A Two-Stage Continuous-Flow Synthesis of Spirooxazine Photochromic Dyes
Mark York 123
Adriana Edenharter 1
1 CSIRO Materials Science and Engineering, Clayton, Vic. 3169, Australia. 
2 Cooperative Research Centre for Polymers, Notting Hill, Vic. 3168, Australia. 
3 Advanced Polymerik Pty Ltd, Notting Hill, Vic. 3168, Australia. 
 
 
Ozonolysis of some complex organic substrates in flow
M. D. Roydhouse 1, W. B. Motherwell 1
A. Constantinou 2, A. Gavriilidis 2
R. Wheeler 3, K. Down 3, I. Campbell 3
1 Dept of Chemistry, University College London, UK
2 Dept of Chemical Engineering, University College London, UK
3 GSK, Stevenage, UK
 
 
Continuous Synthesis and Use of N-Heterocyclic Carbene Copper(I) Complexes from Insoluble Cu2O
Suzanne M. Opalka 1
Jin Kyoon Park 3
Ashley R. Longstreet 2
D. Tyler McQuade 2
1 Department of Chemistry and Biochemistry, Florida State University, USA
2 Department of Chemistry and Chemical Biology, Cornell University, USA
3 Department of Chemistry and Chemical Institute for Functional Materials, Pusan National University, Korea
 
 
 
 

 

An expeditious synthesis of imatinib and analogues utilising flow chemistry methods
Mark D Hopkin, Ian Baxendale, Steven.V.Ley
Dept of Chemistry, University of Cambridge, UK

 

Continuous-flow generation of diazoesters and their direct use in S-H and P-H insertion reactions: synthesis of a-sulfanyl, a-sulfonyl and a-phosphono carboxylates
Hannah E. Bartrum¹
David C. Blakemore² 
Christopher J. Moody¹
Christopher J. Hayes¹
¹ School of Chemistry, University of Nottingham, University Park, Nottingham, NG7 2RD, UK
² Pfizer Neusentis, The Portway Building, Granta Park, Cambridge, CB21 6GS, UK

 

 
Synthesis of Carbohydrate-Functionalised Sequence-Defined Oligo(amidoamine)s by Photochemical ThiolEne Coupling in a Continuous Flow Reactor
Felix Wojcik¹,²
Alexander G. O'Brien¹,²
Sebastian Götze¹,²
Peter H. Seeberger¹,² 
Laura Hartmann¹,²
¹Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Potsdam (Germany)
²Institute for Chemistry and Biochemistry, Freie Universität Berlin,  Berlin (Germany)
 
 
Synthesis of RAFT Block Copolymers in a Multi-Stage Continuous Flow Process Inside a Tubular Reactor
Christian H. Hornung
Xuan Nguyen
Stella Kyi
John Chiefari
Simon Saubern
CSIRO Materials Science & Engineering, Victoria, Australia. 
 
 
 
 
Continuous Flow Synthesis of Organic Electronic Materials : Case Studies in Methodology Translation and Scale-up
Helga Seyler¹
Stefan Haid² 
Tae-Hyuk Kwon¹
David J. Jones¹
Peter Bäuerle²
Andrew B. Holmes¹
Wallace W. H. Wong¹ * 
¹ Bio21 Institute, University of Melbourne, Australia. 
² Institute of Organic Chemistry II and Advanced Materials, University of Ulm, Germany. 
 
Preparation of Arene Chromium Tricarbonyl Complexes Using Continuous-Flow Processing: (n6-C6H5CH3)Cr(CO)3 as an example
Christopher (Xiang) Lee¹, Elizabeth A. Pedrick¹ , Nicholas E. Leadbeater¹
¹Department of Chemistry, University of Connecticut, USA
²Department of Community Medicine and Health Care, University of Connecticut Health Center, USA
 
 
Visible Light-Initiated Preparation of Functionalized Polystyrene Monoliths for Flow Chemistry
Farhan R. Bou-Hamdan¹, Kathleen Krüger¹, Klaus Tauer¹, Tyler McQuade ¹,³ , Peter H. Seeberger ¹,²
¹ Max Planck Institute of Colloids and Interfaces Potsdam, Germany. 
² Institute of Chemistry and Biochemistry, Freie Universität Berlin , Germany. 
³ Department of Chemistry and Biochemistry, Florida State University, USA. 

 

Integrated Continuous Processing and Flow Characterization of RAFT Polymerization in Tubular Flow Reactors
Christian H. Hornung, Xuan Nguyen, Geoff Dumsday, Simon Saubern*
CSIRO Materials Science and Engineering,  Victoria. Australia
 
 
Synthesis of an H3 Antagonist via Sequential One-Pot Additions of a Magnesium Ate Complex and an Amine to a 1,4-Ketoester followed by Carbonyl-Directed Fluoride Addition
Joel M. Hawkins, Pascal Dubé, Mark T. Maloney, Lulin Wei. Marcus Ewing
Stephen M. Chesnut, Joshua R. Denette, Brett M. Lillie, Rajappa Vaidyanathan
Pharmaceutical Sciences, Pfizer Inc., Groton, USA

 

A "Catch-React-Release" Method for the Flow Synthesis of 2-Aminopyrimidines and Preparation of the Imatinib Base
Richard J. Ingham, Elena Riva, Nikzad Nikbin, Ian R. Baxendale, and Steven V. Ley*
Innovative Technology Centre, University of Cambridge, U.K.
 
 
Sustainable and efficient methodology for CLA synthesis and identification
Andres Moreno, Maria Moreno, Maria Victoria Gómez, Cristina Cebrian, Pilar Prieto, Antonio de la Hoz
Departamento de Química Inorgánica, , Universidad de Castilla-La Mancha, Ciudad Real, Spain.

 

 

Continuous Synthesis and Purification by Direct Coupling of a Flow Reactor with Simulated Moving-Bed Chromatography
Alexander G. O’Brien¹ ,  Zoltán Horváth³,  François Lévesque ¹,  Ju Weon Lee³, Andreas Seidel-Morgenstern³, 
Peter H. Seeberger ¹,²
¹ Department for Biomolecular Systems, Max-Planck Institute for Colloids and Interfaces, Potsdam, Germany
² Freie Universität Berlin, Germany
³ Max-Planck Institute for Dynamics of Complex Technical Systems, Magdeburg, Germany
                                       
                                           
A Continuous Flow Process for the Radical Induced End Group Removal of RAFT Polymers
Christian H. Hornung, Almar Postma, Simon Saubern, John Chiefari
CSIRO Materials Science & Engineering, Victoria  Australia
 
                                                               
Continuous Flow Synthesis of Secondary Amides by Tandem Azidation- Amidation of Anilines
Christian Spiteri,  John E. Moses*
School of Chemistry, University of Nottingham, UK
                                                               
 
Asymmetric Homogeneous Hydrogenation in Flow using a Tube-in-Tube Reactor
Sean Newton¹, Steven V. Ley¹, Eva Casas Arcé², Damian M. Grainger²
¹Department of Chemistry, University of Cambridge, U.K. 
²Johnson Matthey Catalysis and Chiral Technology, Cambridge, U.K.

 

 

Continuous Flow Hydrogenation Using an On-Demand Gas Delivery Reactor
Michael A. Mercadante, Christopher B. Kelly, Christopher (Xiang) Lee, Nicholas E. Leadbeater*
Department of Chemistry, University of Connecticut, USA
 
 
An efficient method for the lipase-catalysed resolution and in-line purification of racemic flurbiprofen in a continuous-flow reactor
Lucia Tamborini¹, Diego Romano², Andrea Pinto¹, Arianna Bertolani¹², Francesco Molinari², Paola Conti¹
¹ Dipartimento di Scienze Farmaceutiche ‘Pietro Pratesi’, Universitá degli Studi di Milano, Italy
² Dipartimento di Scienze e Tecnologie Alimentari e Microbiologiche, Universitá degli Studi di Milano, Italy
 
 
Soluble Polymer-Supported Flow Synthesis: A Green Process for the Preparation of Heterocycles
Nicolò Prosa, Raphaël Turgis, Riccardo Piccardi, Marie-Christine Scherrmann
Institut de Chimie Moléculaire et des Matériaux d'Orsay, Université Paris-Sud, France
 
 
Continuous flow synthesis and scale-up of glycine- and taurine-conjugated bile salts
Francesco Venturoni ,  Antimo Gioiello ,  Roccaldo Sardella ,  Benedetto Natalini and Roberto Pellicciari
Dipartimento di Chimica e Tecnologia del Farmaco, Università di Perugia, Italy

 

 

Development of a Continuous Flow Scale-Up Approach of Reflux Inhibitor AZD6906
Tomas Gustafsson
Henrik Sörensen
Fritiof Pontén*
Medicinal Chemistry, AstraZeneca R&D Mölndal, Sweden
 
 
Phase-Transfer Catalysis under Continuous Flow Conditions: An Alternative Approach to the Biphasic Liquid/Liquid O-Alkylation of Phenols
Daniele De Zani²
Matteo Colombo¹  
¹NiKem Research 20021 via Zambeletti 25 Milan Baranzate Italy
²Erregierre, San Paolo D'Argon Bergamo Italy

 

Continuous-Flow Synthesis of the Anti-Malaria Drug Artemisinin
François Lévesque1, Peter H. Seeberger1,2
1Department for Biomolecular Systems, Max-Planck Institute for Colloids and Interfaces, Germany
2Institute for Chemistry and Biochemistry, Freie Universität Berlin, Germany
 
 
Continuous proline catalysis via leaching of solid proline
Suzanne M. Opalka1, Ashley R. Longstreet2 and D. Tyler McQuade2
1Department of Chemistry and Chemical Biology, Cornell University, USA
2Department of Chemistry and Biochemistry, Florida State University,USA
 
 
Scale-Up of Flow-Assisted Synthesis of C2-Symmetric Chiral PyBox Ligands
Claudio Battilocchio¹³, Marcus Baumann¹, Ian R. Baxendale¹, Mariangela Biava³, Matthew O. Kitching¹, Steven V. Ley¹, 
Rainer E. Martin*², Stephan A. Ohnmacht², Nicholas D. C. Tappin¹ 
¹Department of Chemistry, University of Cambridge, UK
² F. Hoffmann-La Roche Ltd., Pharmaceuticals Division,  Basel, Switzerland
³ Department of Pharmaceutical Chemistry and Technology, Sapienza University of Rome, Italy
 
 
Application of Flow Chemistry to the Selective Reduction of Esters to Aldehydes
Juan de M. Muñoz1, Jesús Alcázar1, Antonio de la Hoz2, Angel Díaz-Ortiz2
1Janssen, Toledo, Spain
2Facultad de Ciencias Químicas, Universidad de Castilla-La Mancha, Spain
 
 
Synthesis of Annulated Pyridines by Intramolecular Inverse-Electron-Demand Hetero-Diels-Alder Reaction under Superheated Continuous Flow Conditions
Rainer E. Martin1, Falk Morawitz1, Christoph Kuratli1, André M. Alker2, Alexander I. Alanine1
1Chemistry Technology and Innovation, F. Hoffmann-La Roche Ltd, Basel, Switzerland
2Biostructure Section, F. Hoffmann-La Roche Ltd,Basel, Switzerland
 
 
 
The application of a monolithic triphenylphosphine reagent for conducting Appel reactions in flow microreactors
Kimberley A. Roper1, Heiko Lange1, Anastasios Polyzos1, Malcolm B. Berry2,
Ian R. Baxendale1 and Steven V. Ley1
1Innovative Technology Centre, University of Cambridge
2GlaxoSmithKline, Stevenage, UK
 
 
Continuous Preparation of Arylmagnesium Reagents in Flow with Inline IR Monitoring
Tobias Brodmann¹, Peter Koos¹, Albrecht Metzger¹, Paul Knochel*², Steven V. Ley*¹ 
¹Department of Chemistry, University of Cambridge,  U.K.
²Department of Chemistry, Ludwig Maximilians-Universität München, Germany
 
 
New Insights into Cyclobutenone Rearrangements: A Total Synthesis of the Natural ROS-Generating Anti-Cancer Agent Cribrostatin  (ROS=reactive-oxygen species)
Mubina Mohamed¹, Théo P. Gonçalves¹, Richard J. Whitby¹, Helen F. Sneddon², David C. Harrowven¹
¹Dept of Chemistry, University of Southampton, UK
²GSK Medicines Research Centre, Stevenage, UK
 
 
The Oxygen-Mediated Synthesis of 1,3-Butadiynes in Continuous Flow: Using Teflon AF-2400 to Effect Gas/Liquid Contact
Trine P. Petersen 123, Anastasios Polyzos 14, Matthew O’Brien 1, Trond Ulven 2,
Ian R. Baxendale 1 , Steven V. Ley 1
1 Whiffen Laboratory, University of Cambridge, UK
2 Department of Physics and Chemistry, University of Southern Denmark
3 Discovery Chemistry and DMPK, H. Lundbeck A/S,Denmark
4 CSIRO, Materials Science and Engineering, Australia
 
 
 
Lead Diversification 2: Application to P38, gMTP and lead compounds
M. Abid Masood ¹, Marc Bazin², Mark E. Bunnage¹, Andrew Calabrese³, Mark Cox¹, Sally-Ann Fancy¹, 
Elizabeth Farrant¹, David W. Pearce¹, Manuel Perez¹, Laure Hitzel¹, Torren Peakman¹
¹ Worldwide Medicinal Chemistry, Pfizer, UK
² Hepatochem, Cambridge, MA, USA
³ Celgene San Diego, USA
 
 
A continuous-flow synthesis of annulated and polysubstituted furans from the reaction of ketones and a-haloketones
Mark York
CSIRO Materials Science and Engineering, Australia
Cooperative Research Centre for Polymers, Notting Hill, Australia
 
 
Suzuki-Miyaura Cross-Coupling of Heteroaryl Halides and Arylboronic Acids in Continuous Flow
Timothy Noël and Andrew J. Musacchio
Department of Chemistry, MIT, USA
 
 
The Oxygen-Mediated Synthesis of 1,3-Butadiynes in Continuous Flow: Using Teflon AF-2400 to Effect Gas/Liquid Contact
Trine P. Petersen123, Anastasios Polyzos14, Matthew O’Brien1, Trond Ulven2, Ian R. Baxendale1,
Prof. Steven V. Ley1,*
1Whiffen Laboratory, Department of Chemistry, University of Cambridge (UK)
2Department of Physics and Chemistry, University of Southern Denmark
3Discovery Chemistry and DMPK, H. Lundbeck A/S, Denmark
4CSIRO, Materials Science and Engineering, Victoria, Australia
 
 
 
 
Continuous flow synthesis of conjugated polymers  
Helga Seyler, David J. Jones, Andrew B. Holmes and Wallace W. H. Wong
Bio21 Institute, University of Melbourne, Australia 
 
 
Continuous-flow, palladium-catalysed alkoxycarbonylation reactions using a prototype reactor in which it is possible to load gas and heat simultaneously
Michael A. Mercadante and Nicholas E. Leadbeater
Department of Chemistry, University of Connecticut, USA 
 
 
Teflon AF-2400 mediated gas–liquid contact in continuous flow methoxycarbonylations and in-line FTIR measurement of CO concentration
 Peter Koos, Ulrike Gross, Anastasios Polyzos, Matthew O'Brien, Ian Baxendale and Steven V. Ley
Innovative Technology Centre, University of Cambridge, UK 
 
 
Rapid Access to -Alkoxy and -Amino Acid Derivatives through Safe Continuous-Flow Generation of Diazoesters
  Hannah E. Bartrum1, David C. Blakemore2, Christopher J. Moody1, Christopher J. Hayes1
 1School of Chemistry, University of Nottingham, UK
 2Pfizer Global Research and Development, Sandwich, UK 
 
 
 
Continuous flow photolysis of aryl azides: Preparation of 3H-azepinones
Farhan R. Bou-Hamdan,François Lévesque, Alexander G. O'Brien, Peter H. Seeberger
Max Planck Institute of Colloids and Interfaces, Berlin, Germany   
 
 
Ozonolysis in Flow Using Capillary Reactors
M. D. Roydhouse1, A. Ghaini2, A. Constantinou, A. Cantu-Perez2, W. B. Motherwell1, and A. Gavriilidis2
1Department of Chemistry, University College London, UK
2Department of Chemical Engineering, University College London, UK 
 
 
Nitrile Oxide 1,3-Dipolar Cycloaddition by Dehydration of Nitromethane Derivatives Under Continuous Flow Conditions
Malte Brasholz, Simon Saubern* and G. Paul Savage
CSIRO Materials Science and Engineering, Victoria, Australia. 
 
 
Nitration Chemistry in Continuous Flow using Fuming Nitric Acid in a Commercially Available Flow Reactor  
Cara E. Brocklehurst, Hansjoerg Lehmann, and Luigi La Vecchia
Global Discovery Chemistry, Novartis, Basel, Switzerland 
 
 
Synthesis of a Drug-Like Focused Library of Trisubstituted Pyrrolidines Using Integrated Flow Chemistry and Batch Methods
Marcus Baumann1Ian R. Baxendale1Steven V. Ley1
Christoph Kuratli2,  Rainer E. Martin2,  Josef Schneider2
1Innovative Technology Centre, University of Cambridge, U.K.
2F. Hoffmann-La Roche Ltd., Basel, Switzerland
 
 
Synthesis of (+)-Dumetorine and Congeners by Using Flow Chemistry Technologies
Elena Riva2, Anna Rencurosi1, Stefania Gagliardi1, Daniele Passarella2, Marisa Martinelli1*
1NiKem Research S.r.l., Milan, Italy
2Università degli Studi di Milano,Milan, Italy
 
 
 
 
Preparation of fluoxetine by multiple flow processing steps
Batoul Ahmed-Omer, Adam J. Sanderson
Eli Lilly and Co. Ltd., Lilly Research Centre, UK.
 
 
Oxidation Reactions in Segmented and Continuous Flow Chemical Processing Using an N-(tert-Butyl)phenylsulfinimidoyl Chloride Monolith
Heiko Lange, Matthew J. Capener, Alexander X. Jones, Catherine J. Smith, Nikzad Nikbin, Ian R. Baxendale, Steven V. Ley*
Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK
 
 
Decarboxylative biaryl synthesis in a continuous flow reactor
¹Paul P. Lange , ¹Lukas J. Gooßen , ²Philip Podmore , ²Toby Underwood, ²Nunzio Sciammetta
¹Technische Universität Kaiserslautern, Germany
²Pfizer Global R&D, Sandwich, UK
 
 
Diastereoselective Chain-Elongation Reactions Using Microreactors for Applications in Complex Molecule Assembly
Catherine F. Carter¹, Heiko Lange¹, Daiki Sakai², Ian R. Baxendale¹, Steven V. Ley¹
¹ Innovative Technology Centre, University of Cambridge, UK, CB2 1EW,  UK
² Mitsubishi Tanabe Pharma Corporation,  Yokohama, Japan
 
 
One-Flow, Multistep Synthesis of Nucleosides by Brønsted Acid-Catalyzed Glycosylation
Adam Sniady, Matthew W. Bedore, Timothy F. Jamison
Novartis Institutes for Biomedical Research Inc., Cambridge, USA
MIT, Cambridge, USA 
 
 
An Integrated Flow and Batch-Based Approach for the Synthesis of O-Methyl Siphonazole
Marcus Baumann, Ian R. Baxendale, Malte Brasholz, John J. Hayward, Steven V. Ley, Nikzad Nikbin
Innovative Technology Centre, CambridgeUK
 
 
Flow synthesis of organic azides and the multistep synthesis of imines and amines using a new monolithic triphenylphosphine reagent
Catherine J. Smith, Christopher D. Smith, Nikzad Nikbin, Steven V. Ley , Ian R. Baxendale
Innovative Technology Centre, Cambridge, UK
 
 
 
A fully automated, multistep flow synthesis of 5-amino-4-cyano-1,2,3-triazoles
Catherine J. Smith, Nikzad Nikbin, Steven V. Ley, Heiko Lange , Ian R. Baxendale
Innovative Technology Centre, Cambridge, UK
 
 
A General, One-Step Synthesis of Substituted Indazoles using a Flow Reactor
Rob C. Wheeler, Emma Baxter, Ian B. Campbell, Simon J. F. Macdonald
GlaxoSmithKline, Stevenage, UK
 
 
Continuous flow synthesis of fullerene derivatives
Helga Seyler, Wallace Wing Ho Wong, Dave Jones , Andrew B. Holmes
University Of Melbourne, Australia
 
 
Controlled RAFT Polymerization in a Continuous Flow Microreactor
Christian H. Hornung ,Carlos Guerrero-Sanchez, Malte Brasholz, Simon Saubern, John Chiefari, Graeme Moad, Ezio Rizzardo, San H. Thang
CSIRO Materials Science & Engineering, Victoria, Australia
 
 
 
 
Highly efficient dehydration of carbohydrates to 5-(chloromethyl)furfural (CMF), 5-(hydroxymethyl)furfural (HMF) and levulinic acid by biphasic continuous flow processing
Malte Brasholz , Karin von Känel, Christian H. Hornung, Simon Saubern, John Tsanaktsidis
CSIRO Materials Science & Engineering, Victoria , Australia
 
 
 
Continuous flow thermolysis of azidoacrylates for the synthesis of heterocycles and pharmaceutical intermediates
Alexander G. O'Brien, François Lévesque and Peter H. Seeberger
Max Planck Institute of Colloids and Interfaces, Potsdam, Germany
 
 
Safe and Reliable Synthesis of Diazoketones and Quinoxalines in a Continuous Flow Reactor
Laetitia J. Martin1, Andreas L. Marzinzik1, Steven V. Ley2, Ian R. Baxendale2
1 Novartis Institute for BioMedical Research, Basel, Switzerland
2 Innovative Technology Centre, Department of Chemistry, University of Cambridge
 
 
 
The Continuous-Flow Synthesis of Carboxylic Acids using CO2 in a Tube-In-Tube Gas Permeable Membrane Reactor
Anastasios Polyzos, Matthew O’Brien, Trine P. Petersen, Ian R. Baxendale, Steven V. Ley
Innovative Technology Centre, Department of Chemistry, University of Cambridge
 
 
 
 
A breakthrough method for the accurate addition of reagents in multi-step segmented flow processing
Heiko Lange¹, Catherine F. Carter¹ ,  Mark D. Hopkin¹ ,  Adrian Burke² ,  Jon G. Goode² ,  Ian R. Baxendale¹, Steven V. Ley¹
¹Innovative Technology Centre, University of Cambridge, UK
²Mettler-Toledo AutoChem UK
 
 
 
Continuous Flow Coupling and Decarboxylation Reactions Promoted by Copper Tubing
Yun Zhang1, Timothy F. Jamison2, Sejal Patel1, Nello Mainolfi1
1 Novartis Institutes for Biomedical Research Inc., Cambridge, USA
2 MIT, Cambridge, USA
 
 
Synthesis of β-Keto Esters In-Flow and Rapid Access to Substituted Pyrimidines
Hannah E. Bartrum1, David C. Blakemore2, Christopher J. Moody1, and Christopher J. Hayes1
1 School of Chemistry, University of Nottingham, UK
2 Pfizer Global Research and Development, Sandwich, UK
 
 
Synthesis of 3-Aryl/benzyl-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]isoxazole Derivatives: A Comparison between Conventional, Microwave-Assisted and Flow-Based Methodologies
Sabrina Castellano1, Lucia Tamborini2, Monica Viviano1, Andrea Pinto2, Gianluca Sbardella1, and Paola Conti2
1 Dipartimento di Scienze Farmaceutiche, Universit degli Studi di Salerno, Via Ponte Don Melillo, 84084 Fisciano, Italy
2 Dipartimento di Scienze Farmaceutiche “Pietro Pratesi”, Universit degli Studi di Milano , Italy
 
 
 
 
Flow synthesis of tricyclic spiropiperidines as building blocks for the histrionicotoxin family of alkaloids
Malte Brasholz1 , Brian A. Johnson2, James M. Macdonald1 , Anastasios Polyzos1 , John Tsanaktsidis1 , Simon Saubern1 , Andrew B. Holmes1,and John H. Ryan1 ,
1 CSIRO Molecular and Health Technologies, Victoria, Australia
2 School of Chemistry, Bio 21 Institute, University of Melbourne, Victoria, Australia
 
 
 
A Continuous Flow Process Using a Sequence of Microreactors with In-line IR Analysis for the Preparation of N,N-Diethyl-4-(3-fluorophenylpiperidin-4-ylidenemethyl)benzamide as a Potent and Highly Selective δ-Opioid Receptor Agonist
Zizheng Qian, Ian R. Baxendale, Steven V. Ley
Innovative Technology Centre, University of Cambridge
 
Preparation of arylsulfonyl chlorides by chlorosulfonylation of in situ generated diazonium salts using a continuous flow reactor
Laia Malet-Sanz ,  Julia Madrzak ,  Steven V.Ley and Ian R.Baxendale
Innovative Technology Centre, University of Cambridge
 
 
 
KMnO4-Mediated Oxidation as a Continuous Flow Process
Jorg Sedelmeier , Steven V. Ley , Ian R. Baxendale and Marcus Baumann
Innovative Technology Centre, University of Cambridge
 
 
Synthesis of Highly Substituted Nitropyrrolidines, Nitropyrrolizines and Nitropyrroles via Multicomponent-Multistep Sequences within a Flow Reactor
Marcus Baumann, Ian R. Baxendale, Andreas Kirschning, Steven V. Ley,* and Jens Wegner
Department of Chemistry, University of Cambridge


 
A Gram-Scale Batch and Flow Total Synthesis of Perhydrohistrionicotoxin
Dr. Malte Brasholz1, Dr. James M. Macdonald1,  Dr. Simon Saubern1, Dr. John H. Ryan1, Prof. Dr. Andrew B. Holmes1, 2
1 CSIRO Molecular and Health Technologies, Victoria, Australia
2 School of Chemistry, Bio 21 Institute, University of Melbourne, Victoria, Australia
 
 
Effect of phase transfer chemistry, segmented fluid flow, and sonication on the synthesis of cinnamic esters
Mauro Riccaboni, Elena La Porta, Andrea Martorana and Roberta Attanasio
Department of Medicinal Chemistry, NiKem Research Srl, Milan, Italy
 
 
Continuous Flow Palladium(II)-Catalyzed Oxidative Heck Reactions with Arylboronic Acids
Luke R. Odell 1, Jonas Lindh 1, Tomas Gustafsson 2, Mats Larhed 1 *
1 Organic Pharmaceutical Chemistry, Department of MedChem, Uppsala University, Sweden
2 AstraZeneca R&D Mölndal, Sweden
 
 
 
Reaction of Grignard reagents with carbonyl compounds under continuous flow conditions
E. Riva1, S. Gagliardi2, M. Martinelli2, D. Passarella1, D. Vigo2 and A. Rencurosi2,
1 Dipartimento di Chimica Organica e Industriale, Università degli Studi di Milano,  Milano, Italy
2 NiKem Research S.r.l., , Milan, Italy

http://dx.doi.org/10.1016/j.tet.2010.02.078

 

[3+2] Dipolar cycloadditions of an unstabilised azomethine ylide under continuous flow conditions
Mark Grafton, Andrew C. Mansfield and M. Jonathan
Pfizer Global Research and Development, Sandwich, UK

 

A highly efficient flow reactor process for the synthesis of N-Boc-3,4-dehydro-l-proline methyl ester
Lucia Tamborini, Paola Conti, Andrea Pinto and Carlo De Micheli
Dipartimento di Scienze Farmaceutiche ‘Pietro Pratesi’,
Università degli Studi di Milano, Italy
 
 
 
Efficient Continuous Flow Synthesis of Hydroxamic Acids and Suberoylanilide Hydroxamic Acid Preparation
E. Riva1, S. Gagliardi2, Caterina Mazzoni 2, M. Martinelli2, D. Passarella1, D. Vigo2 and A. Rencurosi2,
1 Dipartimento di Chimica Organica e Industriale, Università degli Studi di Milano, Italy
2 NiKem Research S.r.l., Milan, Italy

 

 
 
 
The application of flow microreactors to the preparation of a family of casein kinase I inhibitors
Francesco Venturoni, Nikzad Nikbin, Steven V. Ley and Ian R. Baxendale
Innovative Technology Centre, Department of Chemistry, University of Cambridge
 
 
Multi-Step Synthesis by Using Modular Flow Reactors: The Preparation of YneOnes and Their Use in Heterocycle Synthesis
Ian R. Baxendale1, Søren C. Schou2, Jörg Sedelmeier1, Steven V. Ley1
1ITC, Department of Chemistry, University of Cambridge
2LEO Pharma, Medicinal Chemistry Research, Denmark
 
 
A Flow Process Using Microreactors for the Preparation of a Quinolone Derivative as a Potent 5HT1B Antagonist
Zizheng Qian, Ian R. Baxendale, Steven V. Ley
Innovative Technology Centre, Department of Chemistry, University of Cambridge

 

A flow-based synthesis of Imatinib: the API of Gleevec
Mark D. Hopkin, Ian R. Baxendale and Steven V. Ley
Innovative Technology Centre, Department of Chemistry, University of Cambridge

 

ReactIR Flow Cell: A New Analytical Tool for Continuous Flow Chemical Processing
Catherine F. Carter1, Heiko Lange1, Steven V. Ley1, Ian R. Baxendale1, Brian Wittkamp2, Jon G. Goode3  and Nigel L. Gaunt3
1 Innovative Technology Centre, Department of Chemistry, University of Cambridge
2 Mettler-Toledo AutoChem, USA
3 Mettler-Toledo AutoChem, UK
 
 
A safe and reliable procedure for the iododeamination of aromatic and heteroaromatic amines in a continuous flow reactor
Laia Malet-Sanz , Julia Madrzak, Rhian S. Holvey and Toby Underwood
Research Chemistry, Pfizer Global Research and Development, Sandwich, UK
 
 
Development of fluorination methods using continuous-flow microreactors
Marcus Baumann, Ian R. Baxendale, Laetitia J. Martin, Steven V. Ley
Innovative Technology Centre, Cambridge, UK
 
 
Multistep Synthesis Using Modular Flow Reactors: Bestmann-Ohira Reagent for the Formation of Alkynes and Triazoles
Ian R. Baxendale1, Steven V. Ley1, Andrew C. Mansfield 2, Christopher D. Smith1
1ITC, Department of Chemistry, University of Cambridge,
2Pfizer Global R&D Research Centre, Sandwich, (UK)

 

A Bifurcated Pathway to Thiazoles and Imidazoles Using a Modular Flow Microreactor
Ian R. Baxendale, Steven V. Ley, Christopher D. Smith, Lucia Tamborini and Ana-Florina Voica
Innovative Technology Centre, Cambridge, UK
 
 
The Use of Diethylaminosulfur Trifluoride (DAST) for Fluorination in a Continuous-Flow Microreactor
Baumann, Marcus, Baxendale, Ian R., Ley, Steven V.
Innovative Technology Centre, Cambridge, UK
 

A modular flow reactor for performing Curtius rearrangements as a continuous flow process
Marcus Baumann1, Ian R. Baxendale1, Steven V. Ley1, Nikzad Nikbin1, Christopher D. Smith1 and Jason P. Tierney2
1 Innovative Technology Centre, Department of Chemistry, University of Cambridge
2 Neurology Lead Discovery Chemistry, GlaxoSmithKline R and D, Harlow, UK
 
 
[3 + 2] Cycloaddition of acetylenes with azides to give 1,4-disubstituted 1,2,3-triazoles in a modular flow reactor
Christopher D. Smith¹ ,  Ian R. Baxendale¹ ,  Steve Lanners¹ ,  John J. Hayward¹ ,  Steven V. Ley¹
Stephen C. Smith²
¹Innovative Technology Centre, University of Cambridge, UK
²Syngenta, Jealots Hill International Research Centre, UK
 
 
Azide monoliths as convenient flow reactors for efficient Curtius rearrangement reactions
Marcus Baumann, Ian R. Baxendale, Steven V. Ley, Nikzad Nikbin and Christopher D. Smith
Innovative Technology Centre, Cambridge, UK
 
 
A Microcapillary Flow Disc Reactor for Organic Synthesis
Christian H. Hornung¹ ,Malcolm R. Mackley² ,Ian R. Baxendale¹ ,Steven V. Ley¹
¹ Department of Chemistry, University of Cambridge
² Department of Chemical Engineering, University of Cambridge 
 
 
A flow reactor process for the synthesis of peptides utilizing immobilized reagents, scavengers and catch and release protocols
Ian R. Baxendale, Steven V. Ley, Christopher D. Smith and Geoffrey K. Tranmer
Innovative Technology Centre, Cambridge, UK
 
 
Fully Automated Flow-Through Synthesis of Secondary Sulfonamides in a Binary Reactor System
Charlotte M. Griffiths-Jones, Mark D. Hopkin, Daniel Jönsson, Steven V. Ley, David J. Tapolczay, Emma Vickerstaffe, and Mark Ladlow
GlaxoSmithKline Cambridge Technology Centre, Cambridge

 

 

Fully Automated Continuous Flow Synthesis of 4,5-Disubstituted Oxazoles
Marcus Baumann , Ian R. Baxendale , Steven V. Ley ,Christoper D. Smith , and Geoffrey K. Tranmer
Innovative Technology Center, University of Cambridge
 
Continuous Flow Ligand-Free Heck Reactions Using Monolithic Pd [0] Nanoparticles
Nikzad Nikbin, Mark Ladlow, and Steven V. Ley
Department of Chemistry, University of Cambridge, UK
 
 
Tagged phosphine reagents to assist reaction work-up by phase-switched scavenging using a modular flow reactor
Christopher D. Smith, Ian Baxendale, Geoffrey Tranmer, Marcus Baumann, Stephen Smith, Russell Lewthwaite and Steven V. Ley
Department of Chemistry, University of Cambridge, UK
 
 
A flow process for the multi-step synthesis of the alkaloid natural product oxomaritidine: a new paradigm for molecular assembly
Ian R. Baxendale ,  Jon Deeley ,  Charlotte M. Griffiths-Jones ,  Steven V. Ley ,  Steen Saaby and Geoffrey K. Tranmer
Innovative Technology Centre, University of Cambridge

 

 

 


Articles:
Follow the Pharma Flow  (published in Speciality Chemicals magazine)
Rapid, Save Investigation and Quantification of Reaction Exotherms (published in Production Engineering Control and Maintenance)

 


 

Posters: