Publications

 

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Below are a selection of recent publications that showcase the Vapourtec technology.

 

Click here for list of peer reviewed publications  
(or here to download whole list as a single PDF )

 

Click here to see magazine articles.

Click here to see posters.

 

Click here to be kept up to date by email when more publications are added.

 

 

 

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Publications

 

 

 

Continuous-Flow Synthesis of the Anti-Malaria Drug Artemisinin

François Lévesque¹, Peter H. Seeberger^1,2

http://dx.doi.org/10.1002/anie.201107446 

 

 

 

Continuous proline catalysis via leaching of solid proline

Suzanne M. Opalka¹, Ashley R. Longstreet² and D. Tyler McQuade²

¹Department of Chemistry and Chemical Biology, Cornell University, USA

²Department of Chemistry and Biochemistry, Florida State University,USA

http://dx.doi.org/10.3762/bjoc.7.197

 

 

Application of Flow Chemistry to the Selective Reduction of Esters to Aldehydes

Juan de M. Muñoz¹, Jesús Alcázar¹, Antonio de la Hoz², Angel Díaz-Ortiz²

¹Janssen, Toledo, Spain

²Facultad de Ciencias Químicas, Universidad de Castilla-La Mancha, Spain

http://dx.doi.org/10.1002/ejoc.201101458

 

 

Synthesis of Annulated Pyridines by Intramolecular Inverse-Electron-Demand Hetero-Diels-Alder Reaction under Superheated Continuous Flow Conditions

Rainer E. Martin¹, Falk Morawitz¹, Christoph Kuratli¹, André M. Alker², Alexander I. Alanine¹

¹Chemistry Technology and Innovation, F. Hoffmann-La Roche Ltd, Basel, Switzerland

²Biostructure Section, F. Hoffmann-La Roche Ltd,Basel, Switzerland

http://dx.doi.org/10.1002/ejoc.201101538

 

 

The application of a monolithic triphenylphosphine reagent for conducting Appel reactions in flow microreactors

Kimberley A. Roper¹, Heiko Lange¹, Anastasios Polyzos¹, Malcolm B. Berry²,

Ian R. Baxendale¹ and Steven V. Ley¹

1Innovative Technology Centre, University of Cambridge

2GlaxoSmithKline, Stevenage, UK

http://dx.doi.org/10.3762/bjoc.7.194

 

Continuous Preparation of Arylmagnesium Reagents in Flow with Inline IR Monitoring

Tobias Brodmann¹, Peter Koos¹, Albrecht Metzger¹, Paul Knochel*², Steven V. Ley*¹ 

¹Department of Chemistry, University of Cambridge,  U.K.

²Department of Chemistry, Ludwig Maximilians-Universität München, Germany

http://dx.doi.org/10.1021/op200275d

 

 

New Insights into Cyclobutenone Rearrangements: A Total Synthesis of the Natural ROS-Generating Anti-Cancer Agent Cribrostatin  (ROS=reactive-oxygen species)

Mubina Mohamed¹, Théo P. Gonçalves¹, Richard J. Whitby¹, Helen F. Sneddon², David C. Harrowven¹

¹Dept of Chemistry, University of Southampton, UK

²GSK Medicines Research Centre, Stevenage, UK

http://dx.doi.org/10.1002/chem.201102263

 

 

The Oxygen-Mediated Synthesis of 1,3-Butadiynes in Continuous Flow: Using Teflon AF-2400 to Effect Gas/Liquid Contact

Trine P. Petersen ^123, Anastasios Polyzos ¹⁴, Matthew O’Brien ¹, Trond Ulven ²,

Ian R. Baxendale ¹ , Steven V. Ley ¹

¹ Whiffen Laboratory, University of Cambridge, UK

² Department of Physics and Chemistry, University of Southern Denmark

³ Discovery Chemistry and DMPK, H. Lundbeck A/S,Denmark

⁴ CSIRO, Materials Science and Engineering, Australia

http://dx.doi.org/10.1002/cssc.201100339

 

 

Lead Diversification 2: Application to P38, gMTP and lead compounds

M. Abid Masood ¹, Marc Bazin², Mark E. Bunnage¹, Andrew Calabrese³, Mark Cox¹, Sally-Ann Fancy¹, 

Elizabeth Farrant¹, David W. Pearce¹, Manuel Perez¹, Laure Hitzel¹, Torren Peakman¹

¹ Worldwide Medicinal Chemistry, Pfizer, UK

² Hepatochem, Cambridge, MA, USA

³ Celgene San Diego, USA

http://dx.doi.org/10.1016/j.bmcl.2011.11.033

 

 

A continuous-flow synthesis of annulated and polysubstituted furans from the reaction of ketones and a-haloketones

Mark York

CSIRO Materials Science and Engineering, Australia

Cooperative Research Centre for Polymers, Notting Hill, Australia

http://dx.doi.org/10.1016/j.tetlet.2011.09.083

 

 

Suzuki-Miyaura Cross-Coupling of Heteroaryl Halides and Arylboronic Acids in Continuous Flow

Timothy Noël and Andrew J. Musacchio

Department of Chemistry, MIT, USA

http://dx.doi.org/10.1021/ol202052q

 

 

The Oxygen-Mediated Synthesis of 1,3-Butadiynes in Continuous Flow: Using Teflon AF-2400 to Effect Gas/Liquid Contact

 

 

Continuous flow synthesis of conjugated polymers  

Helga Seyler, David J. Jones, Andrew B. Holmes and Wallace W. H. Wong

Bio21 Institute, University of Melbourne, Australia 

 

http://dx.doi.org/10.1039/C1CC14315H

 

 

Continuous-flow, palladium-catalysed alkoxycarbonylation reactions using a prototype reactor in which it is possible to load gas and heat simultaneously

 

Michael A. Mercadante and Nicholas E. Leadbeater

Department of Chemistry, University of Connecticut, USA 

http://dx.doi.org/10.1039/C1OB05808H

 

 

Teflon AF-2400 mediated gas–liquid contact in continuous flow methoxycarbonylations and in-line FTIR measurement of CO concentration

 

 Peter Koos, Ulrike Gross, Anastasios Polyzos, Matthew O'Brien, Ian Baxendale and Steven V. Ley

Innovative Technology Centre, University of Cambridge, UK 

http://dx.doi.org/10.1039/C1OB06017A

 

 

 

Rapid Access to
-Alkoxy and
-Amino Acid Derivatives through Safe Continuous-Flow Generation of Diazoesters

 

  Hannah E. Bartrum¹, David C. Blakemore², Christopher J. Moody¹, Christopher J. Hayes¹

 ¹School of Chemistry, University of Nottingham, UK

 

 ²Pfizer Global Research and Development, Sandwich, UK 

 

http://dx.doi.org/10.1002/chem.201101590

 

 

Continuous flow photolysis of aryl azides: Preparation of 3H-azepinones

 

Farhan R. Bou-Hamdan,François Lévesque, Alexander G. O'Brien, Peter H. Seeberger

Max Planck Institute of Colloids and Interfaces, Berlin, Germany   

http://dx.doi.org/10.3762/bjoc.7.129

 

 

Ozonolysis in Flow Using Capillary Reactors

M. D. Roydhouse¹, A. Ghaini², A. Constantinou, A. Cantu-Perez², W. B. Motherwell1, and A. Gavriilidis²

1Department of Chemistry, University College London, UK

²Department of Chemical Engineering, University College London, UK 

http://dx.doi.org/10.1021/op200036d

 

 

Nitrile Oxide 1,3-Dipolar Cycloaddition by Dehydration of Nitromethane Derivatives Under Continuous Flow Conditions

Malte Brasholz, Simon Saubern* and G. Paul Savage

CSIRO Materials Science and Engineering, Victoria, Australia. 

http://dx.doi.org/10.1071/CH11079

 

 

Nitration Chemistry in Continuous Flow using Fuming Nitric Acid in a Commercially Available Flow Reactor  

Cara E. Brocklehurst, Hansjrg Lehmann, and Luigi La Vecchia

Global Discovery Chemistry, Novartis, Basel, Switzerland 

http://dx.doi.org/10.1021/op200055r

 

 

Synthesis of (+)-Dumetorine and Congeners by Using Flow Chemistry Technologies

Elena Riva², Anna Rencurosi¹, Stefania Gagliardi¹, Daniele Passarella², Marisa Martinelli¹*

¹NiKem Research S.r.l., Milan, Italy

²Università degli Studi di Milano,Milan, Italy

http://dx.doi.org/10.1002/chem.201100300

 

 

Preparation of fluoxetine by multiple flow processing steps

Batoul Ahmed-Omer, Adam J. Sanderson

Eli Lilly and Co. Ltd., Lilly Research Centre, UK.

http://dx.doi.org/10.1039/C0OB00906G

 

 

Oxidation Reactions in Segmented and Continuous Flow Chemical Processing Using an N-(tert-Butyl)phenylsulfinimidoyl Chloride Monolith

Heiko Lange, Matthew J. Capener, Alexander X. Jones, Catherine J. Smith, Nikzad Nikbin, Ian R. Baxendale, Steven V. Ley*

Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK

http://dx.doi.org/10.1055/s-0030-1259923

 

Decarboxylative biaryl synthesis in a continuous flow reactor

¹Paul P. Lange , ¹Lukas J. Gooßen , ²Philip Podmore , ²Toby Underwood, ²Nunzio Sciammetta

¹Technische Universität Kaiserslautern, Germany

²Pfizer Global R&D, Sandwich, UK

http://dx.doi.org/10.1039/C0CC05708H

 

 

Diastereoselective Chain-Elongation Reactions Using Microreactors for Applications in Complex Molecule Assembly

Catherine F. Carter¹, Heiko Lange¹, Daiki Sakai², Ian R. Baxendale¹, Steven V. Ley¹

¹ Innovative Technology Centre, University of Cambridge, UK, CB2 1EW,  UK

² Mitsubishi Tanabe Pharma Corporation,  Yokohama, Japan

http://dx.doi.org/10.1002/chem.201003148

 

 

One-Flow, Multistep Synthesis of Nucleosides by Brønsted Acid-Catalyzed Glycosylation

Adam Sniady, Matthew W. Bedore, Timothy F. Jamison

Novartis Institutes for Biomedical Research Inc., Cambridge, USA

MIT, Cambridge, USA 

http://dx.doi.org/10.1002/ange.201006440

 

 

An Integrated Flow and Batch-Based Approach for the Synthesis of O-Methyl Siphonazole

Marcus Baumann, Ian R. Baxendale, Malte Brasholz, John J. Hayward, Steven V. Ley, Nikzad Nikbin

Innovative Technology Centre, Cambridge, UK

http://dx.doi.org/10.1039/C0OB00813C

 

 

Flow synthesis of organic azides and the multistep synthesis of imines and amines using a new monolithic triphenylphosphine reagent

Catherine J. Smith, Christopher D. Smith, Nikzad Nikbin, Steven V. Ley , Ian R. Baxendale

Innovative Technology Centre, Cambridge, UK

http://dx.doi.org/10.1039/C0OB00813C

 

 

A fully automated, multistep flow synthesis of 5-amino-4-cyano-1,2,3-triazoles

Catherine J. Smith, Nikzad Nikbin, Steven V. Ley, Heiko Lange , Ian R. Baxendale

Innovative Technology Centre, Cambridge, UK

http://dx.doi.org/10.1039/C0OB00815J

 

 

A General, One-Step Synthesis of Substituted Indazoles using a Flow Reactor

Rob C. Wheeler, Emma Baxter, Ian B. Campbell, Simon J. F. Macdonald

GlaxoSmithKline, Stevenage, UK

http://pubs.acs.org/doi/abs/10.1021/op100288t

 

 

Continuous flow synthesis of fullerene derivatives

Helga Seyler, Wallace Wing Ho Wong, Dave Jones , Andrew B. Holmes

University Of Melbourne, Australia

http://dx.doi.org/10.1021/jo2001879

 

 

Controlled RAFT Polymerization in a Continuous Flow Microreactor

Christian H. Hornung ,Carlos Guerrero-Sanchez, Malte Brasholz, Simon Saubern, John Chiefari, Graeme Moad, Ezio Rizzardo, San H. Thang

CSIRO Materials Science & Engineering, Victoria, Australia

http://dx.doi.org/10.1021/op1003314

 

 

Highly efficient dehydration of carbohydrates to 5-(chloromethyl)furfural (CMF), 5-(hydroxymethyl)furfural (HMF) and levulinic acid by biphasic continuous flow processing

Malte Brasholz , Karin von Känel, Christian H. Hornung, Simon Saubern, John Tsanaktsidis

CSIRO Materials Science & Engineering, Victoria , Australia

http://dx.doi.org/10.1039/C1GC15107J

 

 

A fully automated, multistep flow synthesis of 5-amino-4-cyano-1,2,3-triazoles

Catherine J. Smith, Nikzad Nikbin, Steven V. Ley, Heiko Lange and Ian R. Baxendale

Innovative Technology Centre, Cambridge, UK

http://dx.doi.org/10.1039/C0OB00815J

 

 

Continuous flow thermolysis of azidoacrylates for the synthesis of heterocycles and pharmaceutical intermediates

Alexander G. O'Brien, François Lévesque and Peter H. Seeberger

Max Planck Institute of Colloids and Interfaces, Potsdam, Germany

http://dx.doi.org/10.1039/C0CC04481D

 

 

Safe and Reliable Synthesis of Diazoketones and Quinoxalines in a Continuous Flow Reactor

Laetitia J. Martin¹, Andreas L. Marzinzik¹, Steven V. Ley², Ian R. Baxendale²

¹ Novartis Institute for BioMedical Research, Basel, Switzerland

² Innovative Technology Centre, Department of Chemistry, University of Cambridge

http://dx.doi.org/10.1021/ol1027927

 

 

The Continuous-Flow Synthesis of Carboxylic Acids using CO₂ in a Tube-In-Tube Gas Permeable Membrane Reactor

Anastasios Polyzos, Matthew O’Brien, Trine P. Petersen, Ian R. Baxendale, Steven V. Ley

Innovative Technology Centre, Department of Chemistry, University of Cambridge

http://dx.doi.org/10.1002/anie.201006618

 

 

Continuous Flow Coupling and Decarboxylation Reactions Promoted by Copper Tubing

Yun Zhang¹, Timothy F. Jamison², Sejal Patel¹, Nello Mainolfi¹

¹ Novartis Institutes for Biomedical Research Inc., Cambridge, USA

² MIT, Cambridge, USA

http://dx.doi.org/10.1021/ol1026848

 

 

Synthesis of β-Keto Esters In-Flow and Rapid Access to Substituted Pyrimidines

Hannah E. Bartrum¹, David C. Blakemore², Christopher J. Moody¹, and Christopher J. Hayes¹

¹ School of Chemistry, University of Nottingham, UK

² Pfizer Global Research and Development, Sandwich, UK

http://dx.doi.org/10.1021/jo101783m

 

 

Synthesis of 3-Aryl/benzyl-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]isoxazole Derivatives: A Comparison between Conventional, Microwave-Assisted and Flow-Based Methodologies

Sabrina Castellano¹, Lucia Tamborini², Monica Viviano¹, Andrea Pinto², Gianluca Sbardella¹, and Paola Conti²

¹ Dipartimento di Scienze Farmaceutiche, Universit degli Studi di Salerno, Via Ponte Don Melillo, 84084 Fisciano, Italy

² Dipartimento di Scienze Farmaceutiche “Pietro Pratesi”, Universit degli Studi di Milano , Italy

http://dx.doi.org/10.1021/jo1014323

 

 

Flow synthesis of tricyclic spiropiperidines as building blocks for the histrionicotoxin family of alkaloids

Malte Brasholz¹ , Brian A. Johnson², James M. Macdonald¹ , Anastasios Polyzos¹ , John Tsanaktsidis¹ , Simon Saubern¹ , Andrew B. Holmes¹,²  and John H. Ryan¹ ,

¹ CSIRO Molecular and Health Technologies, Victoria, Australia

² School of Chemistry, Bio 21 Institute, University of Melbourne, Victoria, Australia http://dx.doi.org/10.1016/j.tet.2010.04.092

 

A Gram-Scale Batch and Flow Total Synthesis of Perhydrohistrionicotoxin

Dr. Malte Brasholz¹, Dr. James M. Macdonald¹,  Dr. Simon Saubern¹, Dr. John H. Ryan¹, Prof. Dr. Andrew B. Holmes¹, ²

¹ CSIRO Molecular and Health Technologies, Victoria, Australia

² School of Chemistry, Bio 21 Institute, University of Melbourne, Victoria, Australia

http://dx.doi.org/10.1002/chem.201090183

 

 

Effect of phase transfer chemistry, segmented fluid flow, and sonication on the synthesis of cinnamic esters

Mauro Riccaboni, Elena La Porta, Andrea Martorana and Roberta Attanasio

Department of Medicinal Chemistry, NiKem Research Srl, Milan, Italy

http://dx.doi.org/10.1016/j.tet.2010.04.031

 

 

Continuous Flow Palladium(II)-Catalyzed Oxidative Heck Reactions with Arylboronic Acids

Luke R. Odell ¹, Jonas Lindh ¹, Tomas Gustafsson ², Mats Larhed ^{1 *}

¹ Organic Pharmaceutical Chemistry, Department of MedChem, Uppsala University, Sweden

² AstraZeneca R&D Mölndal, Sweden

http://dx.doi.org/10.1002/ejoc.201000063

 

 

Reaction of Grignard reagents with carbonyl compounds under continuous flow conditions

E. Riva¹, S. Gagliardi², M. Martinelli², D. Passarella¹, D. Vigo² and A. Rencurosi^2,

¹ Dipartimento di Chimica Organica e Industriale, Università degli Studi di Milano, Via Venezian 21, 20133 Milano, Italy

² NiKem Research S.r.l., , Milan, Italy

http://dx.doi.org/10.1016/j.tet.2010.02.078

 

 

[3+2] Dipolar cycloadditions of an unstabilised azomethine ylide under continuous flow conditions

Mark Grafton, Andrew C. Mansfield and M. Jonathan

Pfizer Global Research and Development, Sandwich, UK

http://dx.doi.org/10.1016/j.tetlet.2009.12.071

 

 

A highly efficient flow reactor process for the synthesis of N-Boc-3,4-dehydro-l-proline methyl ester

Lucia Tamborini, Paola Conti, Andrea Pinto and Carlo De Micheli

Dipartimento di Scienze Farmaceutiche ‘Pietro Pratesi’,

Università degli Studi di Milano, Italy

http://dx.doi.org/10.1016/j.tetasy.2009.12.023

 

 

 

Efficient Continuous Flow Synthesis of Hydroxamic Acids and Suberoylanilide Hydroxamic Acid Preparation

E. Riva¹, S. Gagliardi², Caterina Mazzoni ^2, M. Martinelli², D. Passarella¹, D. Vigo² and A. Rencurosi^2,

¹ Dipartimento di Chimica Organica e Industriale, Università degli Studi di Milano, Italy

² NiKem Research S.r.l., Milan, Italy

http://dx.doi.org/10.1021/jo900144h

 

 

The application of flow microreactors to the preparation of a family of casein kinase I inhibitors

Francesco Venturoni, Nikzad Nikbin, Steven V. Ley and Ian R. Baxendale

Innovative Technology Centre, Department of Chemistry, University of Cambridge

http://dx.doi.org/10.1039/b925327k

 

 

Multi-Step Synthesis by Using Modular Flow Reactors: The Preparation of YneOnes and Their Use in Heterocycle Synthesis

Ian R. Baxendale¹, Søren C. Schou², Jörg Sedelmeier¹, Steven V. Ley¹

¹ITC, Department of Chemistry, University of Cambridge

²LEO Pharma, Medicinal Chemistry Research, Denmark

http://dx.doi.org/10.1055/s-0029-1219431

 

 

A Flow Process Using Microreactors for the Preparation of a Quinolone Derivative as a Potent 5HT_1B Antagonist

Zizheng Qian, Ian R. Baxendale, Steven V. Ley

Innovative Technology Centre, Department of Chemistry, University of Cambridge

http://dx.doi.org/10.1055/s-0029-1219358

 

 

A flow-based synthesis of Imatinib: the API of Gleevec

Mark D. Hopkin, Ian R. Baxendale and Steven V. Ley

Innovative Technology Centre, Department of Chemistry, University of Cambridge

http://dx.doi.org/10.1039/c001550d

 

 

ReactIR Flow Cell: A New Analytical Tool for Continuous Flow Chemical Processing

Catherine F. Carter¹, Heiko Lange¹, Steven V. Ley¹, Ian R. Baxendale¹, Brian Wittkamp², Jon G. Goode³  and Nigel L. Gaunt³

¹ Innovative Technology Centre, Department of Chemistry, University of Cambridge

² Mettler-Toledo AutoChem, USA

³ Mettler-Toledo AutoChem, UK

http://dx.doi.org/10.1021/op900305v

 

 

A safe and reliable procedure for the iododeamination of aromatic and heteroaromatic amines in a continuous flow reactor

Laia Malet-Sanz , Julia Madrzak, Rhian S. Holvey and Toby Underwood

Research Chemistry, Pfizer Global Research and Development, Sandwich, UK

http://dx.doi.org/10.1016/j.tetlet.2009.10.007

 

 

Development of fluorination methods using continuous-flow microreactors

Marcus Baumann, Ian R. Baxendale, Laetitia J. Martin, Steven V. Ley

Innovative Technology Centre, Cambridge, UK

http://dx.doi.org/10.1016/j.tet.2009.05.083

 

Multistep Synthesis Using Modular Flow Reactors: Bestmann-Ohira Reagent for the Formation of Alkynes and Triazoles

Ian R. Baxendale¹, Steven V. Ley¹, Andrew C. Mansfield ², Christopher D. Smith¹

¹ITC, Department of Chemistry, University of Cambridge,

²Pfizer Global R&D Research Centre, Sandwich, (UK)

http://dx.doi.org/10.1002/anie.200900970

 

 

A Bifurcated Pathway to Thiazoles and Imidazoles Using a Modular Flow Microreactor

Ian R. Baxendale, Steven V. Ley, Christopher D. Smith, Lucia Tamborini and Ana-Florina Voica

Innovative Technology Centre, Cambridge, UK

http://dx.doi.org/10.1021/cc800070a

 

 

The Use of Diethylaminosulfur Trifluoride (DAST) for Fluorination in a Continuous-Flow Microreactor

Baumann, Marcus, Baxendale, Ian R., Ley, Steven V.

Innovative Technology Centre, Cambridge, UK

http://dx.doi.org/10.1055/s-2008-1078026

 

 

A modular flow reactor for performing Curtius rearrangements as a continuous flow process

Marcus Baumann¹, Ian R. Baxendale¹, Steven V. Ley¹, Nikzad Nikbin¹, Christopher D. Smith¹ and Jason P. Tierney²

¹ Innovative Technology Centre, Department of Chemistry, University of Cambridge

² Neurology Lead Discovery Chemistry, GlaxoSmithKline R and D, Harlow, UK

http://dx.doi.org/10.1039/b801631n

 

 

Azide monoliths as convenient flow reactors for efficient Curtius rearrangement reactions

Marcus Baumann, Ian R. Baxendale, Steven V. Ley, Nikzad Nikbin and Christopher D. Smith

Innovative Technology Centre, Cambridge, UK

http://dx.doi.org/10.1039/b801634h

 

 

A flow reactor process for the synthesis of peptides utilizing immobilized reagents, scavengers and catch and release protocols

Ian R. Baxendale, Steven V. Ley, Christopher D. Smith and Geoffrey K. Tranmer

Innovative Technology Centre, Cambridge, UK

http://dx.doi.org/10.1039/b612197g

 

 

Fully Automated Flow-Through Synthesis of Secondary Sulfonamides in a Binary Reactor System

Charlotte M. Griffiths-Jones, Mark D. Hopkin, Daniel Jönsson, Steven V. Ley, David J. Tapolczay, Emma Vickerstaffe, and Mark Ladlow

GlaxoSmithKline Cambridge Technology Centre, Cambridge

http://dx.doi.org/10.1021/cc060152b

 

 

Continuous Flow Ligand-Free Heck Reactions Using Monolithic Pd [0] Nanoparticles

Nikzad Nikbin, Mark Ladlow, and Steven V. Ley

Department of Chemistry, University of Cambridge, UK

http://dx.doi.org/10.1021/op7000436

 

 

Tagged phosphine reagents to assist reaction work-up by phase-switched scavenging using a modular flow reactor

Christopher D. Smith, Ian Baxendale, Geoffrey Tranmer, Marcus Baumann, Stephen Smith, Russell Lewthwaite and Steven V. Ley

Department of Chemistry, University of Cambridge, UK

http://dx.doi.org/10.1039/b703033a

 

 

 

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Articles:

Follow the Pharma Flow  (published in Speciality Chemicals magazine)

 

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Posters:

Continuous Flow Synthesis of hydroxamic acids

Continuous Flow Reaction of Grignard Reagents with Carbonyl Compounds

Effect of phase transfer chemistry, segmented fluid flow and sonication  on the synthesis of cinnamic esters

Multistep Synthesis of (+)-Dumetorine Under Continuous Flow Conditions

Ozonolysis in Flow

Regioselective Synthesis of 3-Aminoimidazo[1,2-α]pyrimidines Under Continuous Flow Conditions

Fluorination Chemistry Performed in a Modular Flow Reactor

Continuous Flow Synthesis in Monolithic Reactors

Curtius Rearrangement as a Continuous Flow Process

Continuous flow synthesis of hydroxamic acids

Applications of Flow Synthesis in Medicinal Chemistry

Fully Automated Synthesis of Secondary Sulphonamides in a Binary Flow-Through Reactor System