www.vapourtec.co.uk

Publications

 


Below are a selection of recent publications that showcase the Vapourtec technology.


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Articles:
Follow the Pharma Flow  (published in Speciality Chemicals magazine)
 
Posters:
Fluorination Chemistry Performed in a Modular Flow Reactor
Continuous Flow Synthesis in Monolithic Reactors
Curtius Rearrangement as a Continuous Flow Process
Continuous flow synthesis of hydroxamic acids
Applications of Flow Synthesis in Medicinal Chemistry

Fully Automated Synthesis of Secondary Sulphonamides in a Binary Flow-Through Reactor System
 
 Published Papers:
A safe and reliable procedure for the iododeamination of aromatic and heteroaromatic amines in a continuous flow reactor
Laia Malet-Sanz, Julia Madrzak, Rhian S. Holvey and Toby Underwood
Pfizer Global Research and Development, Sandwich, UK
Development of fluorination methods using continuous-flow microreactors
Marcus Baumann, Ian R. Baxendale, Laetitia J. Martin, Steven V. Ley *
Multistep Synthesis Using Modular Flow Reactors: Bestmann-Ohira Reagent for the Formation of Alkynes and Triazoles
Ian R. Baxendale, Steven V. Ley, Andrew C. Mansfield, Christopher D. Smith
A Bifurcated Pathway to Thiazoles and Imidazoles Using a Modular Flow Microreactor
Ian R. Baxendale, Steven V. Ley, Christopher D. Smith, Lucia Tamborini and Ana-Florina Voica
The Use of Diethylaminosulfur Trifluoride (DAST) for Fluorination in a Continuous-Flow Microreactor
 Marcus Baumann, Ian R. Baxendale, Steven V. Ley
A modular flow reactor for performing Curtius rearrangements as a continuous flow process
Marcus Baumann, Ian R. Baxendale, Steven V. Ley, Nikzad Nikbin, Christopher D. Smith and Jason P. Tierney
Azide monoliths as convenient flow reactors for efficient Curtius rearrangement reactions
Marcus Baumann, Ian R. Baxendale, Steven V. Ley, Nikzad Nikbin and Christopher D. Smith
A flow reactor process for the synthesis of peptides utilizing immobilized reagents, scavengers and catch and release protocols
Ian R. Baxendale, Steven V. Ley, Christopher D. Smith and Geoffrey K. Tranmer
Fully Automated Flow-Through Synthesis of Secondary Sulfonamides in a Binary Reactor System
Charlotte M. Griffiths-Jones, Mark D. Hopkin, Daniel Jönsson, Steven V. Ley, David J. Tapolczay, Emma Vickerstaffe and Mark Ladlow
Continuous Flow Ligand-Free Heck Reactions Using Monolithic Pd [0] Nanoparticles
Nikzad Nikbin, Mark Ladlow and Steven V. Ley
Tagged phosphine reagents to assist reaction work-up by phase-switched scavenging using a modular flow reactor
Christopher D. Smith, Ian R. Baxendale, Geoffrey K. Tranmer, Marcus Baumann, Stephen C. Smith, Russell A. Lewthwaite and Steven V. Ley