Publications
To date, the Vapourtec R Series system has featured in more than 65 peer reviewed publications.
Follow the links below to see the sort of things that are possible, but note that most published papers will require a journal subscription.
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Continuous Flow Hydrogenation Using an On-Demand Gas Delivery Reactor
Michael A. Mercadante, Christopher B. Kelly, Christopher (Xiang) Lee, Nicholas E. Leadbeater*
Department of Chemistry, University of Connecticut, USA
An efficient method for the lipase-catalysed resolution and in-line purification of racemic flurbiprofen in a continuous-flow reactor
Lucia Tamborini¹, Diego Romano², Andrea Pinto¹, Arianna Bertolani¹², Francesco Molinari², Paola Conti¹
¹ Dipartimento di Scienze Farmaceutiche ‘Pietro Pratesi’, Universitá degli Studi di Milano, Italy
² Dipartimento di Scienze e Tecnologie Alimentari e Microbiologiche, Universitá degli Studi di Milano, Italy
Soluble Polymer-Supported Flow Synthesis: A Green Process for the Preparation of Heterocycles
Nicolò Prosa, Raphaël Turgis, Riccardo Piccardi, Marie-Christine Scherrmann
Institut de Chimie Moléculaire et des Matériaux d'Orsay, Université Paris-Sud, France
Continuous flow synthesis and scale-up of glycine- and taurine-conjugated bile salts
Francesco Venturoni , Antimo Gioiello , Roccaldo Sardella , Benedetto Natalini and Roberto Pellicciari
Dipartimento di Chimica e Tecnologia del Farmaco, Università di Perugia, Italy
Development of a Continuous Flow Scale-Up Approach of Reflux Inhibitor AZD6906
Tomas Gustafsson
Henrik Sörensen
Fritiof Pontén*
Medicinal Chemistry, AstraZeneca R&D Mölndal, Sweden
Phase-Transfer Catalysis under Continuous Flow Conditions: An Alternative Approach to the Biphasic Liquid/Liquid O-Alkylation of Phenols
Daniele De Zani²
Matteo Colombo¹
¹NiKem Research 20021 via Zambeletti 25 Milan Baranzate Italy
²Erregierre, San Paolo D'Argon Bergamo Italy
Continuous-Flow Synthesis of the Anti-Malaria Drug Artemisinin
François Lévesque1, Peter H. Seeberger1,2
1Department for Biomolecular Systems, Max-Planck Institute for Colloids and Interfaces, Germany
2Institute for Chemistry and Biochemistry, Freie Universität Berlin, Germany
Continuous proline catalysis via leaching of solid proline
Suzanne M. Opalka1, Ashley R. Longstreet2 and D. Tyler McQuade2
1Department of Chemistry and Chemical Biology, Cornell University, USA
2Department of Chemistry and Biochemistry, Florida State University,USA
Application of Flow Chemistry to the Selective Reduction of Esters to Aldehydes
Juan de M. Muñoz1, Jesús Alcázar1, Antonio de la Hoz2, Angel Díaz-Ortiz2
1Janssen, Toledo, Spain
2Facultad de Ciencias Químicas, Universidad de Castilla-La Mancha, Spain
Synthesis of Annulated Pyridines by Intramolecular Inverse-Electron-Demand Hetero-Diels-Alder Reaction under Superheated Continuous Flow Conditions
Rainer E. Martin1, Falk Morawitz1, Christoph Kuratli1, André M. Alker2, Alexander I. Alanine1
1Chemistry Technology and Innovation, F. Hoffmann-La Roche Ltd, Basel, Switzerland
2Biostructure Section, F. Hoffmann-La Roche Ltd,Basel, Switzerland
The application of a monolithic triphenylphosphine reagent for conducting Appel reactions in flow microreactors
Kimberley A. Roper1, Heiko Lange1, Anastasios Polyzos1, Malcolm B. Berry2,
Ian R. Baxendale1 and Steven V. Ley1
1Innovative Technology Centre, University of Cambridge
2GlaxoSmithKline, Stevenage, UK
Continuous Preparation of Arylmagnesium Reagents in Flow with Inline IR Monitoring
Tobias Brodmann¹, Peter Koos¹, Albrecht Metzger¹, Paul Knochel*², Steven V. Ley*¹
¹Department of Chemistry, University of Cambridge, U.K.
²Department of Chemistry, Ludwig Maximilians-Universität München, Germany
New Insights into Cyclobutenone Rearrangements: A Total Synthesis of the Natural ROS-Generating Anti-Cancer Agent Cribrostatin (ROS=reactive-oxygen species)
Mubina Mohamed¹, Théo P. Gonçalves¹, Richard J. Whitby¹, Helen F. Sneddon², David C. Harrowven¹
¹Dept of Chemistry, University of Southampton, UK
²GSK Medicines Research Centre, Stevenage, UK
The Oxygen-Mediated Synthesis of 1,3-Butadiynes in Continuous Flow: Using Teflon AF-2400 to Effect Gas/Liquid Contact
Trine P. Petersen 123, Anastasios Polyzos 14, Matthew O’Brien 1, Trond Ulven 2,
Ian R. Baxendale 1 , Steven V. Ley 1
1 Whiffen Laboratory, University of Cambridge, UK
2 Department of Physics and Chemistry, University of Southern Denmark
3 Discovery Chemistry and DMPK, H. Lundbeck A/S,Denmark
4 CSIRO, Materials Science and Engineering, Australia
Lead Diversification 2: Application to P38, gMTP and lead compounds
M. Abid Masood ¹, Marc Bazin², Mark E. Bunnage¹, Andrew Calabrese³, Mark Cox¹, Sally-Ann Fancy¹,
Elizabeth Farrant¹, David W. Pearce¹, Manuel Perez¹, Laure Hitzel¹, Torren Peakman¹
¹ Worldwide Medicinal Chemistry, Pfizer, UK
² Hepatochem, Cambridge, MA, USA
³ Celgene San Diego, USA
A continuous-flow synthesis of annulated and polysubstituted furans from the reaction of ketones and a-haloketones
Mark York
CSIRO Materials Science and Engineering, Australia
Cooperative Research Centre for Polymers, Notting Hill, Australia
Suzuki-Miyaura Cross-Coupling of Heteroaryl Halides and Arylboronic Acids in Continuous Flow
Timothy Noël and Andrew J. Musacchio
Department of Chemistry, MIT, USA
The Oxygen-Mediated Synthesis of 1,3-Butadiynes in Continuous Flow: Using Teflon AF-2400 to Effect Gas/Liquid Contact
Trine P. Petersen123, Anastasios Polyzos14, Matthew O’Brien1, Trond Ulven2, Ian R. Baxendale1,
Prof. Steven V. Ley1,*
1Whiffen Laboratory, Department of Chemistry, University of Cambridge (UK)
2Department of Physics and Chemistry, University of Southern Denmark
3Discovery Chemistry and DMPK, H. Lundbeck A/S, Denmark
4CSIRO, Materials Science and Engineering, Victoria, Australia
Continuous flow synthesis of conjugated polymers
Helga Seyler, David J. Jones, Andrew B. Holmes and Wallace W. H. Wong
Bio21 Institute, University of Melbourne, Australia
Continuous-flow, palladium-catalysed alkoxycarbonylation reactions using a prototype reactor in which it is possible to load gas and heat simultaneously
Michael A. Mercadante and Nicholas E. Leadbeater
Department of Chemistry, University of Connecticut, USA
Teflon AF-2400 mediated gas–liquid contact in continuous flow methoxycarbonylations and in-line FTIR measurement of CO concentration
Peter Koos, Ulrike Gross, Anastasios Polyzos, Matthew O'Brien, Ian Baxendale and Steven V. Ley
Innovative Technology Centre, University of Cambridge, UK
Rapid Access to -Alkoxy and -Amino Acid Derivatives through Safe Continuous-Flow Generation of Diazoesters
Hannah E. Bartrum1, David C. Blakemore2, Christopher J. Moody1, Christopher J. Hayes1
1School of Chemistry, University of Nottingham, UK
2Pfizer Global Research and Development, Sandwich, UK
Continuous flow photolysis of aryl azides: Preparation of 3H-azepinones
Farhan R. Bou-Hamdan,François Lévesque, Alexander G. O'Brien, Peter H. Seeberger
Max Planck Institute of Colloids and Interfaces, Berlin, Germany
Ozonolysis in Flow Using Capillary Reactors
M. D. Roydhouse1, A. Ghaini2, A. Constantinou, A. Cantu-Perez2, W. B. Motherwell1, and A. Gavriilidis2
1Department of Chemistry, University College London, UK
2Department of Chemical Engineering, University College London, UK
Nitrile Oxide 1,3-Dipolar Cycloaddition by Dehydration of Nitromethane Derivatives Under Continuous Flow Conditions
Malte Brasholz, Simon Saubern* and G. Paul Savage
CSIRO Materials Science and Engineering, Victoria, Australia.
Nitration Chemistry in Continuous Flow using Fuming Nitric Acid in a Commercially Available Flow Reactor
Cara E. Brocklehurst, Hansjrg Lehmann, and Luigi La Vecchia
Global Discovery Chemistry, Novartis, Basel, Switzerland
Synthesis of a Drug-Like Focused Library of Trisubstituted Pyrrolidines Using Integrated Flow Chemistry and Batch Methods
Marcus Baumann1, Ian R. Baxendale1, Steven V. Ley1,
Christoph Kuratli2, Rainer E. Martin2, Josef Schneider2
1Innovative Technology Centre, University of Cambridge, U.K.
2F. Hoffmann-La Roche Ltd., Basel, Switzerland
Synthesis of (+)-Dumetorine and Congeners by Using Flow Chemistry Technologies
Elena Riva2, Anna Rencurosi1, Stefania Gagliardi1, Daniele Passarella2, Marisa Martinelli1*
1NiKem Research S.r.l., Milan, Italy
2Università degli Studi di Milano,Milan, Italy
Preparation of fluoxetine by multiple flow processing steps
Batoul Ahmed-Omer, Adam J. Sanderson
Eli Lilly and Co. Ltd., Lilly Research Centre, UK.
Oxidation Reactions in Segmented and Continuous Flow Chemical Processing Using an N-(tert-Butyl)phenylsulfinimidoyl Chloride Monolith
Heiko Lange, Matthew J. Capener, Alexander X. Jones, Catherine J. Smith, Nikzad Nikbin, Ian R. Baxendale, Steven V. Ley*
Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK
Decarboxylative biaryl synthesis in a continuous flow reactor
¹Paul P. Lange , ¹Lukas J. Gooßen , ²Philip Podmore , ²Toby Underwood, ²Nunzio Sciammetta
¹Technische Universität Kaiserslautern, Germany
²Pfizer Global R&D, Sandwich, UK
Diastereoselective Chain-Elongation Reactions Using Microreactors for Applications in Complex Molecule Assembly
Catherine F. Carter¹, Heiko Lange¹, Daiki Sakai², Ian R. Baxendale¹, Steven V. Ley¹
¹ Innovative Technology Centre, University of Cambridge, UK, CB2 1EW, UK
² Mitsubishi Tanabe Pharma Corporation, Yokohama, Japan
One-Flow, Multistep Synthesis of Nucleosides by Brønsted Acid-Catalyzed Glycosylation
Adam Sniady, Matthew W. Bedore, Timothy F. Jamison
Novartis Institutes for Biomedical Research Inc., Cambridge, USA
MIT, Cambridge, USA
An Integrated Flow and Batch-Based Approach for the Synthesis of O-Methyl Siphonazole
Marcus Baumann, Ian R. Baxendale, Malte Brasholz, John J. Hayward, Steven V. Ley, Nikzad Nikbin
Innovative Technology Centre, Cambridge, UK
Flow synthesis of organic azides and the multistep synthesis of imines and amines using a new monolithic triphenylphosphine reagent
Catherine J. Smith, Christopher D. Smith, Nikzad Nikbin, Steven V. Ley , Ian R. Baxendale
Innovative Technology Centre, Cambridge, UK
A fully automated, multistep flow synthesis of 5-amino-4-cyano-1,2,3-triazoles
Catherine J. Smith, Nikzad Nikbin, Steven V. Ley, Heiko Lange , Ian R. Baxendale
Innovative Technology Centre, Cambridge, UK
A General, One-Step Synthesis of Substituted Indazoles using a Flow Reactor
Rob C. Wheeler, Emma Baxter, Ian B. Campbell, Simon J. F. Macdonald
GlaxoSmithKline, Stevenage, UK
Continuous flow synthesis of fullerene derivatives
Helga Seyler, Wallace Wing Ho Wong, Dave Jones , Andrew B. Holmes
University Of Melbourne, Australia
Controlled RAFT Polymerization in a Continuous Flow Microreactor
Christian H. Hornung ,Carlos Guerrero-Sanchez, Malte Brasholz, Simon Saubern, John Chiefari, Graeme Moad, Ezio Rizzardo, San H. Thang
CSIRO Materials Science & Engineering, Victoria, Australia
Highly efficient dehydration of carbohydrates to 5-(chloromethyl)furfural (CMF), 5-(hydroxymethyl)furfural (HMF) and levulinic acid by biphasic continuous flow processing
Malte Brasholz , Karin von Känel, Christian H. Hornung, Simon Saubern, John Tsanaktsidis
CSIRO Materials Science & Engineering, Victoria , Australia
A fully automated, multistep flow synthesis of 5-amino-4-cyano-1,2,3-triazoles
Catherine J. Smith, Nikzad Nikbin, Steven V. Ley, Heiko Lange and Ian R. Baxendale
Innovative Technology Centre, Cambridge, UK
Continuous flow thermolysis of azidoacrylates for the synthesis of heterocycles and pharmaceutical intermediates
Alexander G. O'Brien, François Lévesque and Peter H. Seeberger
Max Planck Institute of Colloids and Interfaces, Potsdam, Germany
Safe and Reliable Synthesis of Diazoketones and Quinoxalines in a Continuous Flow Reactor
Laetitia J. Martin1, Andreas L. Marzinzik1, Steven V. Ley2, Ian R. Baxendale2
1 Novartis Institute for BioMedical Research, Basel, Switzerland
2 Innovative Technology Centre, Department of Chemistry, University of Cambridge
The Continuous-Flow Synthesis of Carboxylic Acids using CO2 in a Tube-In-Tube Gas Permeable Membrane Reactor
Anastasios Polyzos, Matthew O’Brien, Trine P. Petersen, Ian R. Baxendale, Steven V. Ley
Innovative Technology Centre, Department of Chemistry, University of Cambridge
Continuous Flow Coupling and Decarboxylation Reactions Promoted by Copper Tubing
Yun Zhang1, Timothy F. Jamison2, Sejal Patel1, Nello Mainolfi1
1 Novartis Institutes for Biomedical Research Inc., Cambridge, USA
2 MIT, Cambridge, USA
Synthesis of β-Keto Esters In-Flow and Rapid Access to Substituted Pyrimidines
Hannah E. Bartrum1, David C. Blakemore2, Christopher J. Moody1, and Christopher J. Hayes1
1 School of Chemistry, University of Nottingham, UK
2 Pfizer Global Research and Development, Sandwich, UK
Synthesis of 3-Aryl/benzyl-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]isoxazole Derivatives: A Comparison between Conventional, Microwave-Assisted and Flow-Based Methodologies
Sabrina Castellano1, Lucia Tamborini2, Monica Viviano1, Andrea Pinto2, Gianluca Sbardella1, and Paola Conti2
1 Dipartimento di Scienze Farmaceutiche, Universit degli Studi di Salerno, Via Ponte Don Melillo, 84084 Fisciano, Italy
2 Dipartimento di Scienze Farmaceutiche “Pietro Pratesi”, Universit degli Studi di Milano , Italy
Flow synthesis of tricyclic spiropiperidines as building blocks for the histrionicotoxin family of alkaloids
Malte Brasholz1 , Brian A. Johnson2, James M. Macdonald1 , Anastasios Polyzos1 , John Tsanaktsidis1 , Simon Saubern1 , Andrew B. Holmes1,2 and John H. Ryan1 ,
1 CSIRO Molecular and Health Technologies, Victoria, Australia
2 School of Chemistry, Bio 21 Institute, University of Melbourne, Victoria, Australia
A Gram-Scale Batch and Flow Total Synthesis of Perhydrohistrionicotoxin
Dr. Malte Brasholz1, Dr. James M. Macdonald1, Dr. Simon Saubern1, Dr. John H. Ryan1, Prof. Dr. Andrew B. Holmes1, 2
1 CSIRO Molecular and Health Technologies, Victoria, Australia
2 School of Chemistry, Bio 21 Institute, University of Melbourne, Victoria, Australia
Effect of phase transfer chemistry, segmented fluid flow, and sonication on the synthesis of cinnamic esters
Mauro Riccaboni, Elena La Porta, Andrea Martorana and Roberta Attanasio
Department of Medicinal Chemistry, NiKem Research Srl, Milan, Italy
Continuous Flow Palladium(II)-Catalyzed Oxidative Heck Reactions with Arylboronic Acids
Luke R. Odell 1, Jonas Lindh 1, Tomas Gustafsson 2, Mats Larhed 1 *
1 Organic Pharmaceutical Chemistry, Department of MedChem, Uppsala University, Sweden
2 AstraZeneca R&D Mölndal, Sweden
Reaction of Grignard reagents with carbonyl compounds under continuous flow conditions
1 Dipartimento di Chimica Organica e Industriale, Università degli Studi di Milano, Milano, Italy
2 NiKem Research S.r.l., , Milan, Italy
http://dx.doi.org/10.1016/j.tet.2010.02.078
[3+2] Dipolar cycloadditions of an unstabilised azomethine ylide under continuous flow conditions
Mark Grafton, Andrew C. Mansfield and M. Jonathan
Pfizer Global Research and Development, Sandwich, UK
A highly efficient flow reactor process for the synthesis of N-Boc-3,4-dehydro-l-proline methyl ester
Lucia Tamborini, Paola Conti, Andrea Pinto and Carlo De Micheli
Dipartimento di Scienze Farmaceutiche ‘Pietro Pratesi’,
Università degli Studi di Milano, Italy
Efficient Continuous Flow Synthesis of Hydroxamic Acids and Suberoylanilide Hydroxamic Acid Preparation
E. Riva1, S. Gagliardi2, Caterina Mazzoni 2, M. Martinelli2, D. Passarella1, D. Vigo2 and A. Rencurosi2,
1 Dipartimento di Chimica Organica e Industriale, Università degli Studi di Milano, Italy
2 NiKem Research S.r.l., Milan, Italy
The application of flow microreactors to the preparation of a family of casein kinase I inhibitors
Francesco Venturoni, Nikzad Nikbin, Steven V. Ley and Ian R. Baxendale
Innovative Technology Centre, Department of Chemistry, University of Cambridge
Multi-Step Synthesis by Using Modular Flow Reactors: The Preparation of YneOnes and Their Use in Heterocycle Synthesis
Ian R. Baxendale1, Søren C. Schou2, Jörg Sedelmeier1, Steven V. Ley1
1ITC, Department of Chemistry, University of Cambridge
2LEO Pharma, Medicinal Chemistry Research, Denmark
A Flow Process Using Microreactors for the Preparation of a Quinolone Derivative as a Potent 5HT1B Antagonist
Zizheng Qian, Ian R. Baxendale, Steven V. Ley
Innovative Technology Centre, Department of Chemistry, University of Cambridge
A flow-based synthesis of Imatinib: the API of Gleevec
Mark D. Hopkin, Ian R. Baxendale and Steven V. Ley
Innovative Technology Centre, Department of Chemistry, University of Cambridge
ReactIR Flow Cell: A New Analytical Tool for Continuous Flow Chemical Processing
Catherine F. Carter1, Heiko Lange1, Steven V. Ley1, Ian R. Baxendale1, Brian Wittkamp2, Jon G. Goode3 and Nigel L. Gaunt3
1 Innovative Technology Centre, Department of Chemistry, University of Cambridge
2 Mettler-Toledo AutoChem, USA
3 Mettler-Toledo AutoChem, UK
A safe and reliable procedure for the iododeamination of aromatic and heteroaromatic amines in a continuous flow reactor
Research Chemistry, Pfizer Global Research and Development, Sandwich, UK
Development of fluorination methods using continuous-flow microreactors
Marcus Baumann, Ian R. Baxendale, Laetitia J. Martin, Steven V. Ley
Innovative Technology Centre, Cambridge, UK
Multistep Synthesis Using Modular Flow Reactors: Bestmann-Ohira Reagent for the Formation of Alkynes and Triazoles
Ian R. Baxendale1, Steven V. Ley1, Andrew C. Mansfield 2, Christopher D. Smith1
1ITC, Department of Chemistry, University of Cambridge,
2Pfizer Global R&D Research Centre, Sandwich, (UK)
A Bifurcated Pathway to Thiazoles and Imidazoles Using a Modular Flow Microreactor
Ian R. Baxendale, Steven V. Ley, Christopher D. Smith, Lucia Tamborini and Ana-Florina Voica
Innovative Technology Centre, Cambridge, UK
The Use of Diethylaminosulfur Trifluoride (DAST) for Fluorination in a Continuous-Flow Microreactor
Baumann, Marcus, Baxendale, Ian R., Ley, Steven V.
Innovative Technology Centre, Cambridge, UK
A modular flow reactor for performing Curtius rearrangements as a continuous flow process
Marcus Baumann1, Ian R. Baxendale1, Steven V. Ley1, Nikzad Nikbin1, Christopher D. Smith1 and Jason P. Tierney2
1 Innovative Technology Centre, Department of Chemistry, University of Cambridge
2 Neurology Lead Discovery Chemistry, GlaxoSmithKline R and D, Harlow, UK
Azide monoliths as convenient flow reactors for efficient Curtius rearrangement reactions
Marcus Baumann, Ian R. Baxendale, Steven V. Ley, Nikzad Nikbin and Christopher D. Smith
Innovative Technology Centre, Cambridge, UK
A flow reactor process for the synthesis of peptides utilizing immobilized reagents, scavengers and catch and release protocols
Ian R. Baxendale, Steven V. Ley, Christopher D. Smith and Geoffrey K. Tranmer
Innovative Technology Centre, Cambridge, UK
Fully Automated Flow-Through Synthesis of Secondary Sulfonamides in a Binary Reactor System
Charlotte M. Griffiths-Jones, Mark D. Hopkin, Daniel Jönsson, Steven V. Ley, David J. Tapolczay, Emma Vickerstaffe, and Mark Ladlow
GlaxoSmithKline Cambridge Technology Centre, Cambridge
Continuous Flow Ligand-Free Heck Reactions Using Monolithic Pd [0] Nanoparticles
Nikzad Nikbin, Mark Ladlow, and Steven V. Ley
Department of Chemistry, University of Cambridge, UK
Tagged phosphine reagents to assist reaction work-up by phase-switched scavenging using a modular flow reactor
Christopher D. Smith, Ian Baxendale, Geoffrey Tranmer, Marcus Baumann, Stephen Smith, Russell Lewthwaite and Steven V. Ley
Department of Chemistry, University of Cambridge, UK
| Articles: |
| Follow the Pharma Flow (published in Speciality Chemicals magazine) |
| Rapid, Save Investigation and Quantification of Reaction Exotherms (published in Production Engineering Control and Maintenance) |
| Posters: |
