Flow Synthesis Online - November 2009
Welcome to the Flow Synthesis Online newsletter.
This publication is released bi-monthly and will showcase new applications, events, and equipment in the Flow Synthesis world.
There's clearly a lot of technology development going on in flow ! Below you can see Vapourtec's announcement of the first true nitration capable flow chemistry system. There are also links to a free webinar demonstrating Mettler Toledo's ReactIR™ flow cell and publications involving online HPLC (Merck), and online phase separation (University of Cardiff).
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Product News
Vapourtec System Now Ready For Real Nitrations !
| The Vapourtec R Series system is now available in an acid resistant version, capable of using fuming nitric acid and concentrated sulphuric acid (among others). Safe, straightforward nitrations with easy scaleup are now possible. In fact one user has demonstrated a 50g/hr nitration with fuming nitric acid in the new system within 2 days of installation ! |
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Events
Upcoming Events
Free Webinar Showcasing the Mettler Toledo ReactIR™ flow cell.
On November 19th (at 3 different times) this device will be demonstrated. It is presented as a convenient inline analytical tool for continuous flow chemistry processing.
The flow cell, operated with ATR technology, is attached inline using standard Omnifit® connections. With the established iC IR 4.0 software the consumption of reagents and formation of products can be monitored in real-time, allowing for rapid optimization. Unstable reactive intermediates can also be observed in situ, giving mechanistic insight to complex transformations.
Guest presenters include Professor Steven Ley, winner of the 2009 Tetrahedron Prize.
The device will be demonstrated with several flow systems, including the Vapourtec R Series (used for a Curtius Rearrangment).
Click here to see more or sign up for the webinar
Publications
Optimizing the Deprotection of the Amine Protecting p-Methoxyphenyl Group in an Automated Microreactor Platform
Kaspar Koch, Bram J. A. van Weerdenburg, Jorge M. M. Verkade, Pieter J. Nieuwland, Floris P. J. T. Rutjes* and Jan C. M. van Hest*
Radboud University Nijmegen, Institute for Molecules and Materials, Heyendaalseweg 135, NL-6525 AJ Nijmegen, The Netherlands
Org. Process Res. Dev., 2009
Three factors (temperature, stoichiometry and reaction temperature) were investigated in continuous flow microreactors in an automated fashion for optimization of the removal of the p-methoxyphenyl (PMP) protecting group, thereby consuming only minute amounts of substrate (0.2 mg/sample). The optimal reaction conditions were also applied to a larger microreactor system, in which the corresponding free amine was obtained at a preparative scale.
Click here to go straight to the publication
| The Continuous-Flow Synthesis of Ibuprofen
Andrew R. Bogdan 2, Sarah L. Poe 2, Daniel C. Kubis 2, Steven J. Broadwater 2, D. Tyler McQuade 1 Let relief flow forth! A three-step, continuous-flow synthesis of ibuprofen was accomplished using a simplified microreactor. By designing a synthesis in which excess reagents and byproducts are compatible with downstream reactions, no intermediate purification or isolation steps are required. Click here to go straight to the publication
Online Analysis of Flowing Streams Using Microflow HPLC Christopher J. Welch*, Xiaoyi Gong*, James Cuff, Sarah Dolman, Jason Nyrop, Fiona Lin and Hallena Rogers The application of a recently developed online HPLC reaction sampling instrument for monitoring flow chemistry reactions is described. |
Flash Chemistry: Fast Organic Chemistry in Microsystems (Book review)
Klaus F. Jensen
Massachusetts Institute of Technology
J. Am. Chem. Soc., 2009
"This book is a useful addition to the growing number of reviews on flow chemistry"
Click here to go straight to the publication
| Liquid/liquid phase separation: characterisation of a novel device capable of separating particle carrying multiphase flows
Oliver K. Castell, Christopher J. Allender and David A. Barrow Capilliary forces on the microscale are exploited to create a continuous flow liquid–liquid phase separator. Segmented flow regimes of immiscible fluids are generated and subsequently separated into their component phases through an array of high aspect ratio, laser machined, separation ducts (36 µm wide, 130 µm deep) in a planar, integrated, polytetrafluoroethylene (PTFE) microdevice. A controlled pressure differential across the phase separator architecture facilitates the selective passage of the wetting, organic, phase through the separator ducts, enabling separation of microfluidic multiphase flow streams. The reported device is demonstrated to separate water and chloroform segmented flow regimes at flow rates up to 0.4 ml min-1. |
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