www.vapourtec.co.uk

Flow Synthesis Online - January 2010

 

Welcome to the Flow Synthesis Online newsletter.

This publication is released bi-monthly and will showcase new applications, events, and equipment in the Flow Synthesis world.



Product News

ImagePrecise cooled reactions :
-70oC with no recirculating chiller !

The Vapourtec R Series system now comes with a facility for cooled reactions. Simple, remarkably compact and easy to use, this facility permits one or two reactors to be independently controlled at temperatures down to -70oC.
 

Best of all, the system requires no bulky, expensive external recirculating chiller and can be added as an upgrade to existing R Series systems.
 

Click here to read more



Is it your first time ?

If this is the first issue of the newsletter that you've looked at, you might like to take a look at what you've missed in some previous issues.

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Publications

 


Multi-Step Synthesis by Using Modular Flow Reactors:
The Preparation of Yneones and Their Use in Heterocycle Synthesis

ImageIan R. Baxendale, Dr. 1,
Søren C. Schou 2,
Jörg Sedelmeier, Dr. 1,
Steven V. Ley, Prof. 1

1ITC, Department of Chemistry, University of Cambridge
2LEO Pharma, Medicinal Chemistry Research (Denmark)

Multi-step in flow: The palladium-catalysed acylation of terminal alkynes for the synthesis of yneones as well as their further transformation to various heterocycles in a continuous-flow mode is presented. Furthermore, an extension of the simple flow configuration that allows for easy batch splitting and the generation of a heterocyclic library is described (see scheme).

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A Safe and Reliable Procedure for the Iododeamination of Aromatic and Heteroaromatic Amines in a Continuous Flow Reactor

ImageLaia Malet-Sanz, Julia Madrzak, Rhian S. Holvey and Toby Underwood

Research Chemistry, Pfizer Global Research and Development, Sandwich, UK

A method for the safe and reliable iododeamination of aromatic and heteroaromatic amines under copper-free conditions is described and its scope is evaluated.

   click here to go straight to the publication

 

 

Fully Automated Continuous Flow Synthesis of Highly Functionalized Imidazo[1,2-a] Heterocycles

ImageAnanda Herath, Russell Dahl and Nicholas D. P. Cosford

Program in Apoptosis and Cell Death Research and Conrad Prebys Center for Chemical Genomics, Burnham Institute for Medical Research, La Jolla, USA

The first continuous flow synthesis of imidazo[1,2-a]pyridine-2-carboxylic acids directly from 2-aminopyridines and bromopyruvic acid has been developed, representing a significant advance over the corresponding in-flask method. The process was applied to the multistep synthesis of imidazo[1,2-a]pyridine-2-carboxamides, including a Mur ligase inhibitor, using a two microreactor, multistep continuous flow process without isolation of intermediates.

click here to go straight to the publication