Application Note 15- Bromination of Ketones     Bromination with molecular bromine in batch mode usually requires slow and careful addition of the bromine reagent to control thermal kinetics, and often results in poor selectivity. This study demonstrates safe bromination in flow, giving rapid complete conversion and high selectivity.     Request This Application Note>>         Application Note 14- Phase Transfer Catalysis     Biphasic reactions, whereby the reaction takes place at the interface between two immiscible solvents, can be cleanly and reproducibly performed in a continuous flow reactor. This study demonstrates phase transfer catalyzed (PTC) alkylation of ß-Keto ester under segmented flow conditions.     Request This Application Note>>         Application Note 13- Suzuki Coupling     A solid supported Pd catalyst column is used to perform a flow based Suzuki Coupling, synthesising *3-phenylpyridine***, with short residence time and high conversion.     Request This Application Note>>         Application Note 12- Weinreb Amidation     Weinreb amidation, utilizing trimethylaluminium to activate amine for condensation with ester. Risky in batch due to pyrophoric reagent and potential thermal runaway with high energy intermediate, reaction is safely performed in a flow reactor with very short residence times, high yield and excellent conversion.     Request This Application Note>>           Application Note 1- Reaction Profiling using a 'Dual-Core™' Tubing Reactor     An SNAr reaction using a continuous flow tubing reactor containing a dual core to illustrate reaction profiling. The smaller capacity reactor minimises sample wastage to obtain optimal reaction conditions that may be scaled-up in the larger reactor.     Request This Application Note>>           Application Note 2- Optimisation of Step 1 in the Synthesis of Linezolid using a 'Dual-Core™' Tubing Reactor     The smaller volume tubing reactor was used to determine optimal flow-through conditions suitable for the scale-up synthesis of the intermediate 3 required for the preparation of UpJohn's oxazolidinone antibiotic linezolid (Zyvox®).     Request This Application Note>>           Application Note 3- Scale up SNAr using 12mL Tubing Reactor     Example of the scaled-up preparation of SNAr using 12ml tubing reactor and 2 Knauer pumps.     Request This Application Note>>           Application Note 4- Scale up SNAr using 4 Reactor Channels in Series     Example of the scaled-up preparation of SNAr using the R-2PLUS Pumping Module and 4 x 10ml Tubing Reactors in series.     Request This Application Note>>           Application Note 5- Heck C-C Coupling using Monolithic Nanoparticular Pd[0] PACT Reactor Cartridge     Example of using the R-2PLUS Pumping Module and the R-2 Flow Reactor Heater with reactor columns to perform Polymer Assisted Continuous flow-Through (PACT) chemistry.     Request This Application Note>>           Application Note 6- Transfer Hydrogenation using a Monolithic Nanoparticular Pd[0] PACT Reactor Cartridge     Example of transfer Hydrogenation reactions using the R2+ Pumping Module and the R-4 Flow Reactor in combination with a reactor column without the need for Hydrogen gas.     Request This Application Note>>           Application Note 7- Flow -Through Ester Hydrolysis under Superheated Conditions     This Application Note illustrates how the R-2 pump/injector and R-4 flow reactor modules can bereadily used to perform flow-through chemistry under superheated conditions.     Request This Application Note>>           Application Note 9- Amide Formation using 'Catch and Release'     This Application Note illustrates how the R-2 pump/injector and R-4 flow reactor modules can be used to prepare amides uilising polymer-assisted continuous flow-through (PACT) chemistry.     Request This Application Note>>           Application Note 10- Heterocycle Formation in Flow: 4,5-Disubstituted Oxazoles     This Application Note illustrates how the R-2 pump/injector and R-4 flow reactor modules can beused to prepare oxazoles utilising a combination of a tubing reactor and polymer-assistedcontinuous flow-through (PACT) reactors     Request This Application Note>>           Application Note 11- Array Synthesis using Loop Injection and a Tubing Reactor Combined with a Scavenger Column     R2 pump/injector and R4 flow reactor module used with a flow reactor and a PACT scavenger column to perform sequential array synthesis employing simultaneous loop injection.     Request This Application Note>>